New Flavonoids from the leaves and stems of Sedum formosanum (Crassulaceae)

IF 1.3 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2024-05-10 DOI:10.1016/j.phytol.2024.05.003

Takayuki Mizuno , Takahisa Nakane , Hari Prasad Devkota , Takuro Ito , Goro Kokubugata , Tsukasa Iwashina

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Abstract

As a series of the phytochemical research of the family Crassulaceae, the flavonoids of Sedum formosanum from two Taiwanese and one Japanese sites were isolated and characterized by UV spectra, HR-MS, LC-MS, acid hydrolysis, NMR, and HPLC and TLC comparisons with authentic samples. Eight new flavonoids (21, 22, 24-26 and 28-30) including two flavones and six isoflavones were isolated from the leaves and stems, together with 24 known compounds (1-20, 23, 27, 31 and 32), and identified as chrysoeriol 7-O-[6´´-(3-hydroxy-3-methylglutaroyl)glucoside] (21), chrysoeriol 7-O-[6´´-(5´´´-methoxy-3-hydroxy-3-methyglutaroyl)glucoside] (22), 3´-O-methylorobol 7-O-rutinoside (24), 3´-O-methylorobol 7-O-arabinosyl-(1→2)-glucoside (25), 3´-O-methylorobol 7-O-arabinosyl-(1→6)-glucoside (26), orobol 3´,4´-dimethyl ether 7-O-rutinoside (28), orobol 3´,4´-dimethyl ether 7-O-sophoroside (29) and orobol 3´,4´-dimethyl ether 7-O-arabinosyl-(1→6)-glucoside (30). The samples were collected in three sites of Taiwan and Japan, and geographic chemical variation was observed among their sites.

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从景天科植物（Sedum formosanum）的叶和茎中提取的新黄酮类化合物

通过紫外光谱、HR-MS、LC-MS、酸水解、核磁共振、HPLC和TLC与真品的比较，分离并表征了台湾两地和日本一处景天科植物的黄酮类化合物，作为景天科植物化学研究的一个系列。从叶和茎中分离出 8 种新的黄酮类化合物（21、22、24-26 和 28-30），包括 2 种黄酮和 6 种异黄酮，以及 24 种已知化合物（1-20、23、27、31 和 32），并鉴定为 Chrysoeriol 7-O-[6´´-（3-羟基-3-甲基戊二酰基）葡萄糖苷]（21）、Chrysoeriol 7-O-[6´´-（5´´-甲氧基-3-羟基-3-甲基戊二酰基）葡萄糖苷]（22）、3´-O-methylorobol 7-O-rutinoside (24)、3´-O-methylorobol 7-O-arabinosyl-(1→2)-glucoside (25)、3´-O-methylorobol 7-O-arabinosyl-(1→6)-glucoside (26)、 orobol 3´、4´-二甲醚 7-O-芸香糖苷（28）、奥罗波尔 3´，4´-二甲醚 7-O-槐糖苷（29）和奥罗波尔 3´，4´-二甲醚 7-O-阿拉伯糖基-（1→6）-葡萄糖苷（30）。这些样品分别在台湾和日本的三个地点采集，并在不同地点观察到了地理化学差异。

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.