Evaluation of genotoxic damage, production reactive oxygen and nitrogen species in Plasmodium yoelii yoelii exposed to sodium metavanadate

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology Pub Date : 2024-05-09 DOI:10.1016/j.etap.2024.104465

Brenda Casarrubias-Tabarez , Norma Rivera-Fernández , Norberto Alarcón-Herrera , Gabriela Guerrero-Palomo , Marcela Rojas-Lemus , Nelly López-Valdez , Jhony Anacleto-Santos , Adriana Gonzalez-Villalva , Martha Ustarroz-Cano , Teresa I. Fortoul

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引用次数: 0

Abstract

Malaria represents the greatest global health burden among all parasitic diseases, with drug resistance representing the primary obstacle to control efforts. Sodium metavanadate (NaVO₃) exhibits antimalarial activity against the Plasmodium yoelii yoelii (Pyy), yet its precise antimalarial mechanism remains elusive. This study aimed to assess the antimalarial potential of NaVO₃, evaluate its genotoxicity, and determine the production of reactive oxygen and nitrogen species (ROS/RNS) in Pyy. CD-1 mice were infected and divided into two groups: one treated orally with NaVO₃ (10 mg/kg/day for 4 days) and the other untreated. A 50% decrease in parasitemia was observed in treated mice. All experimental days demonstrated DNA damage in exposed parasites, along with an increase in ROS and RNS on the fifth day, suggesting a possible parasitostatic effect. The results indicate that DNA is a target of NaVO₃, but further studies are necessary to fully elucidate the mechanisms underlying its antimalarial activity.

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评估暴露于偏钒酸钠的yoelii yoelii疟原虫的基因毒性损伤、活性氧和氮物种的产生情况

在所有寄生虫病中，疟疾对全球健康造成的负担最大，而抗药性则是控制疟疾的主要障碍。偏钒酸钠（NaVO3）对疟原虫（Pyy）具有抗疟活性，但其确切的抗疟机制仍难以确定。本研究旨在评估 NaVO3 的抗疟潜力，评价其遗传毒性，并确定 Pyy 中活性氧和氮物种（ROS/RNS）的产生情况。CD-1 小鼠被感染后分为两组：一组口服 NaVO3（10 毫克/公斤/天，连续 4 天），另一组未接受治疗。经治疗的小鼠寄生虫血症减少了 50%。所有的实验天数都表明，暴露的寄生虫 DNA 受到损伤，第五天 ROS 和 RNS 增加，这表明可能存在寄生虫抑制作用。结果表明，DNA 是 NaVO3 的靶标，但要全面阐明其抗疟活性的机制，还需要进一步的研究。

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来源期刊

Environmental toxicology and pharmacology 医学-毒理学

CiteScore

7.00

自引率

4.70%

发文量

185

审稿时长

34 days

期刊介绍： Environmental Toxicology and Pharmacology publishes the results of studies concerning toxic and pharmacological effects of (human and veterinary) drugs and of environmental contaminants in animals and man. Areas of special interest are: molecular mechanisms of toxicity, biotransformation and toxicokinetics (including toxicokinetic modelling), molecular, biochemical and physiological mechanisms explaining differences in sensitivity between species and individuals, the characterisation of pathophysiological models and mechanisms involved in the development of effects and the identification of biological markers that can be used to study exposure and effects in man and animals. In addition to full length papers, short communications, full-length reviews and mini-reviews, Environmental Toxicology and Pharmacology will publish in depth assessments of special problem areas. The latter publications may exceed the length of a full length paper three to fourfold. A basic requirement is that the assessments are made under the auspices of international groups of leading experts in the fields concerned. The information examined may either consist of data that were already published, or of new data that were obtained within the framework of collaborative research programmes. Provision is also made for the acceptance of minireviews on (classes of) compounds, toxicities or mechanisms, debating recent advances in rapidly developing fields that fall within the scope of the journal.