Associations between exposure to phthalates and liver function among women undergoing assisted reproductive technology

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology Pub Date : 2024-05-09 DOI:10.1016/j.etap.2024.104463

Yi Wang , Li Yin , Yao-Yao Du , Hong-Mei Liao , Juan Li , Wen Yao , Xiao-Qiong Yuan , Qing-Chun Guo , Tao-Ran Deng , Na Guo , Min Zhang , Qiang Zeng , Chong Liu , Yu-Feng Li

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Abstract

Phthalates can induce hepatotoxicity in animal studies. We aimed to assess the associations of individual and mixture of urinary phthalate metabolites with serum liver function indicators among 764 women undergoing assisted reproductive technology (ART). In linear models, we observed inverse correlations between urinary mono-benzyl phthalate and serum total protein (TP) as well as globulin (β=–0.27 and –0.23, respectively, P<0.05). Additionally, negative associations were identified between mono-isobutyl phthalate and mono-butyl phthalate (MBP) and aspartate aminotransferase-to-alanine transaminase ratio (AST/ALT) (P<0.05). MBP and the sum of all phthalate metabolites (∑all.phth.m) were positively associated with bilirubin, with β ranging from 0.14 to 0.47. Most phthalate metabolites were also positively related to gamma-glutamyl transferase (GGT) (all P<0.05). In Bayesian kernel machine regression models, phthalate mixture was positively associated with bilirubin and GGT, whereas inversely associated with AST/ALT and TP. Our results suggest that phthalate exposure may impair liver function among women undergoing ART.

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接受辅助生殖技术的妇女接触邻苯二甲酸盐与肝功能之间的关系

在动物实验中，邻苯二甲酸盐可诱发肝毒性。我们的目的是评估 764 名接受辅助生殖技术（ART）的女性尿液中邻苯二甲酸酯代谢物的个体和混合物与血清肝功能指标之间的关系。在线性模型中，我们观察到尿液中邻苯二甲酸单苄酯与血清总蛋白（TP）和球蛋白之间存在反相关性（β=-0.27 和 -0.23，P<0.05）。此外，邻苯二甲酸单异丁酯和邻苯二甲酸单丁酯（MBP）与天门冬氨酸氨基转移酶-丙氨酸转氨酶比率（AST/ALT）呈负相关（P<0.05）。MBP 和所有邻苯二甲酸酯代谢物的总和（∑all.phth.m）与胆红素呈正相关，β 值在 0.14 至 0.47 之间。大多数邻苯二甲酸酯代谢物还与γ-谷氨酰转移酶（GGT）呈正相关（均为 P<0.05）。在贝叶斯核机器回归模型中，邻苯二甲酸酯混合物与胆红素和 GGT 呈正相关，而与 AST/ALT 和 TP 呈反相关。我们的研究结果表明，接触邻苯二甲酸盐可能会损害接受抗逆转录病毒疗法的妇女的肝功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Environmental toxicology and pharmacology 医学-毒理学

CiteScore

7.00

自引率

4.70%

发文量

185

审稿时长

34 days

期刊介绍： Environmental Toxicology and Pharmacology publishes the results of studies concerning toxic and pharmacological effects of (human and veterinary) drugs and of environmental contaminants in animals and man. Areas of special interest are: molecular mechanisms of toxicity, biotransformation and toxicokinetics (including toxicokinetic modelling), molecular, biochemical and physiological mechanisms explaining differences in sensitivity between species and individuals, the characterisation of pathophysiological models and mechanisms involved in the development of effects and the identification of biological markers that can be used to study exposure and effects in man and animals. In addition to full length papers, short communications, full-length reviews and mini-reviews, Environmental Toxicology and Pharmacology will publish in depth assessments of special problem areas. The latter publications may exceed the length of a full length paper three to fourfold. A basic requirement is that the assessments are made under the auspices of international groups of leading experts in the fields concerned. The information examined may either consist of data that were already published, or of new data that were obtained within the framework of collaborative research programmes. Provision is also made for the acceptance of minireviews on (classes of) compounds, toxicities or mechanisms, debating recent advances in rapidly developing fields that fall within the scope of the journal.