Role of umbilical cord mesenchymal stromal cells in skin rejuvenation.

IF 6.4 1区医学 Q1 CELL & TISSUE ENGINEERING

npj Regenerative Medicine Pub Date : 2024-05-10 DOI:10.1038/s41536-024-00363-1

Le Chang, Wei-Wen Fan, He-Ling Yuan, Xin Liu, Qiang Wang, Guang-Ping Ruan, Xing-Hua Pan, Xiang-Qing Zhu

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引用次数: 0

Abstract

Aging is the main cause of many degenerative diseases. The skin is the largest and the most intuitive organ that reflects the aging of the body. Under the interaction of endogenous and exogenous factors, there are cumulative changes in the structure, function, and appearance of the skin, which are characterized by decreased synthesis of collagen and elastin, increased wrinkles, relaxation, pigmentation, and other aging characteristics. skin aging is inevitable, but it can be delayed. The successful isolation of mesenchymal stromal cells (MSC) in 1991 has greatly promoted the progress of cell therapy in human diseases. The International Society for Cellular Therapy (ISCT) points out that the MSC is a kind of pluripotent progenitor cells that have self-renewal ability (limited) in vitro and the potential for mesenchymal cell differentiation. This review mainly introduces the role of perinatal umbilical cord-derived MSC(UC-MSC) in the field of skin rejuvenation. An in-depth and systematic understanding of the mechanism of UC-MSCs against skin aging is of great significance for the early realization of the clinical transformation of UC-MSCs. This paper summarized the characteristics of skin aging and summarized the mechanism of UC-MSCs in skin rejuvenation reported in recent years. In order to provide a reference for further research of UC-MSCs to delay skin aging.

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脐带间充质基质细胞在皮肤年轻化中的作用。

衰老是许多退化性疾病的主要原因。皮肤是反映人体衰老的最大、最直观的器官。在内源性和外源性因素的相互作用下，皮肤的结构、功能和外观都会发生累积性变化，表现为胶原蛋白和弹性蛋白合成减少、皱纹增多、松弛、色素沉着等衰老特征。皮肤衰老是不可避免的，但可以延缓。1991 年间充质基质细胞（MSC）的成功分离极大地推动了细胞疗法在人类疾病中的应用。国际细胞治疗学会（ISCT）指出，间充质干细胞是一种具有体外自我更新能力（有限）和间充质细胞分化潜能的多能祖细胞。本综述主要介绍围产期脐带间充质干细胞（UC-MSC）在嫩肤领域的作用。深入系统地了解UC-间充质干细胞抗皮肤衰老的机制，对于早日实现UC-间充质干细胞的临床转化具有重要意义。本文总结了皮肤衰老的特点，归纳了近年来报道的UC-MSCs在皮肤年轻化中的作用机制。以期为进一步研究UC-MSCs延缓皮肤衰老提供参考。

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来源期刊

npj Regenerative Medicine Engineering-Biomedical Engineering

CiteScore

10.00

自引率

1.40%

发文量

审稿时长

12 weeks

期刊介绍： Regenerative Medicine, an innovative online-only journal, aims to advance research in the field of repairing and regenerating damaged tissues and organs within the human body. As a part of the prestigious Nature Partner Journals series and in partnership with ARMI, this high-quality, open access journal serves as a platform for scientists to explore effective therapies that harness the body's natural regenerative capabilities. With a focus on understanding the fundamental mechanisms of tissue damage and regeneration, npj Regenerative Medicine actively encourages studies that bridge the gap between basic research and clinical tissue repair strategies.