Obesity-Related Traits Mediate the Effects of Educational Attainment on the Risk of Varicose Veins, Venous Thromboembolism, and Phlebitis.

IF 5 2区医学 Q1 HEMATOLOGY

Thrombosis and haemostasis Pub Date : 2024-10-01 Epub Date: 2024-05-10 DOI:10.1055/s-0044-1786970

Hong-Cheng Du, Bai-Yang Deng

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引用次数: 0

Abstract

Background: The extent to which educational attainment (EA) influences the risk of varicose veins (VVs), venous thromboembolism (VTE), and phlebitis occurrence, whether this pathway is mediated by obesity-related traits, and the proportion of their mediation is unknown.

Methods: A Mendelian randomization (MR) design was used to genetically investigate the causal effects of EA on the risk of VV, VTE, and phlebitis and to assess the mediating effect of obesity-related traits. Causal effects were estimated using primarily the multiplicative random-effects inverse variance-weighted method. This was supplemented by Cochran's Q-statistic, MR-Egger regression, MR funnel plots, and leave-one-out test to evaluate the reliability of the results. For the individual mediation effect, the coefficient product method was mainly utilized to estimate.

Results: An increase in genetically predicted EA was associated with a lower risk of VV, VTE, and phlebitis, as well as lower body mass index, basal metabolic rate, hip circumference, and waist circumference. As genetically predicted body mass index, basal metabolic rate, hip circumference, and waist circumference increased, the risk of developing VV, VTE, and phlebitis increased, respectively. Body mass index, basal metabolic rate, hip circumference, and waist circumference were identified as mediators of the protective effects of EA on VV, VTE, and phlebitis.

Conclusion: The findings support a causal relationship between higher EA and lower risk of VV, VTE, and phlebitis. Obesity-related traits play a significant mediating role in these pathways, and there are interactions between them, with hip circumference mediating these pathways relatively independently from the other three.

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与肥胖有关的特质可调节教育程度对静脉曲张、静脉血栓栓塞症和静脉炎风险的影响。

背景：教育程度（EA）对静脉曲张（VVs）、静脉血栓栓塞症（VTE）和静脉炎发生风险的影响程度、这一途径是否由肥胖相关特质介导以及它们的介导比例尚不清楚：方法：采用孟德尔随机化（MR）设计，从遗传学角度研究EA对VV、VTE和静脉炎风险的因果效应，并评估肥胖相关特征的中介效应。因果效应主要采用乘法随机效应逆方差加权法进行估计。此外，还辅以科克兰Q统计量、MR-Egger回归、MR漏斗图和leave-one-out检验来评估结果的可靠性。对于个体中介效应，主要采用系数乘积法进行估计：结果：基因预测 EA 的增加与 VV、VTE 和静脉炎风险的降低以及体重指数、基础代谢率、臀围和腰围的降低有关。随着基因预测的体重指数、基础代谢率、臀围和腰围的增加，发生 VV、VTE 和静脉炎的风险也分别增加。体质指数、基础代谢率、臀围和腰围被确定为 EA 对 VV、VTE 和静脉炎的保护作用的介导因素：结论：研究结果支持较高的 EA 与较低的 VV、VTE 和静脉炎风险之间存在因果关系。肥胖相关特征在这些途径中起着重要的中介作用，而且它们之间存在相互作用，臀围对这些途径的中介作用相对独立于其他三个途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Thrombosis and haemostasis 医学-外周血管病

CiteScore

11.90

自引率

9.00%

发文量

140

审稿时长

1 months

期刊介绍： Thrombosis and Haemostasis publishes reports on basic, translational and clinical research dedicated to novel results and highest quality in any area of thrombosis and haemostasis, vascular biology and medicine, inflammation and infection, platelet and leukocyte biology, from genetic, molecular & cellular studies, diagnostic, therapeutic & preventative studies to high-level translational and clinical research. The journal provides position and guideline papers, state-of-the-art papers, expert analysis and commentaries, and dedicated theme issues covering recent developments and key topics in the field.