Alteration of multilayer network perspective on gray and white matter connectivity in obstructive sleep apnea.

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY

Sleep and Breathing Pub Date : 2024-08-01 Epub Date: 2024-05-11 DOI:10.1007/s11325-024-03059-4

Dong Ah Lee, Ho-Joon Lee, Kang Min Park

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Abstract

Purpose: The objective of this research was to examine changes in the neural networks of both gray and white matter in individuals with obstructive sleep apnea (OSA) in comparison to those without the condition, employing a comprehensive multilayer network analysis.

Methods: Patients meeting the criteria for OSA were recruited through polysomnography, while a control group of healthy individuals matched for age and sex was also assembled. Utilizing T1-weighted imaging, a morphometric similarity network was crafted to represent gray matter, while diffusion tensor imaging provided structural connectivity for constructing a white matter network. A multilayer network analysis was then performed, employing graph theory methodologies.

Results: We included 40 individuals diagnosed with OSA and 40 healthy participants in our study. Analysis revealed significant differences in various global network metrics between the two groups. Specifically, patients with OSA exhibited higher average degree overlap and average multilayer clustering coefficient (28.081 vs. 23.407, p < 0.001; 0.459 vs. 0.412, p = 0.004), but lower multilayer modularity (0.150 vs. 0.175, p = 0.001) compared to healthy controls. However, no significant differences were observed in average multiplex participation, average overlapping strength, or average weighted multiplex participation between the patients with OSA and healthy controls. Moreover, several brain regions displayed notable differences in degree overlap at the nodal level between patients with OSA and healthy controls.

Conclusion: Remarkable alterations in the multilayer network, indicating shifts in both gray and white matter, were detected in patients with OSA in contrast to their healthy counterparts. Further examination at the nodal level unveiled notable changes in regions associated with cognition, underscoring the effectiveness of multilayer network analysis in exploring interactions across brain layers.

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多层网络对阻塞性睡眠呼吸暂停患者灰质和白质连通性的影响。

目的：本研究的目的是通过综合多层网络分析，研究阻塞性睡眠呼吸暂停（OSA）患者灰质和白质的神经网络与非阻塞性睡眠呼吸暂停患者的对比变化：方法：通过多导睡眠监测仪招募符合 OSA 标准的患者，同时招募年龄和性别相匹配的健康人作为对照组。利用T1加权成像技术，构建了一个形态计量相似性网络来代表灰质，而扩散张量成像技术则为构建白质网络提供了结构连接性。然后利用图论方法进行多层网络分析：我们在研究中纳入了 40 名确诊为 OSA 的患者和 40 名健康参与者。分析结果显示，两组患者在各种全局网络指标上存在明显差异。具体来说，OSA 患者表现出更高的平均程度重叠度和平均多层聚类系数（28.081 vs. 23.407，p 结论：OSA 患者的多层聚类系数发生了显著变化：与健康人相比，OSA 患者的多层网络发生了显著变化，表明灰质和白质都发生了移动。在节点水平上的进一步检查揭示了与认知相关区域的显著变化，突出了多层网络分析在探索大脑各层相互作用方面的有效性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sleep and Breathing 医学-呼吸系统

CiteScore

5.20

自引率

4.00%

发文量

222

审稿时长

3-8 weeks

期刊介绍： The journal Sleep and Breathing aims to reflect the state of the art in the international science and practice of sleep medicine. The journal is based on the recognition that management of sleep disorders requires a multi-disciplinary approach and diverse perspectives. The initial focus of Sleep and Breathing is on timely and original studies that collect, intervene, or otherwise inform all clinicians and scientists in medicine, dentistry and oral surgery, otolaryngology, and epidemiology on the management of the upper airway during sleep. Furthermore, Sleep and Breathing endeavors to bring readers cutting edge information about all evolving aspects of common sleep disorders or disruptions, such as insomnia and shift work. The journal includes not only patient studies, but also studies that emphasize the principles of physiology and pathophysiology or illustrate potentially novel approaches to diagnosis and treatment. In addition, the journal features articles that describe patient-oriented and cost-benefit health outcomes research. Thus, with peer review by an international Editorial Board and prompt English-language publication, Sleep and Breathing provides rapid dissemination of clinical and clinically related scientific information. But it also does more: it is dedicated to making the most important developments in sleep disordered breathing easily accessible to clinicians who are treating sleep apnea by presenting well-chosen, well-written, and highly organized information that is useful for patient care.