Polycyclic aromatic hydrocarbons exposure and arterial stiffness-related plasma miRNAs: A panel study

IF 4.2 3区环境科学与生态学 Q2 ENVIRONMENTAL SCIENCES

Environmental toxicology and pharmacology Pub Date : 2024-05-08 DOI:10.1016/j.etap.2024.104464

Ziqian Zhang , Conghua Bai , Lei Zhao, Linlin Liu, Wenting Guo, Miao Liu, Huihua Yang, Xuefeng Lai, Xiaomin Zhang, Liangle Yang

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Abstract

The underlying mechanisms between polycyclic aromatic hydrocarbons (PAHs) exposure and arterial stiffness are poorly understood. We carried out a panel study involving three repeated surveys to examine the associations of individual and mixture of PAHs exposure with arterial stiffness-related miRNAs among 123 community adults. In linear mixed-effect (LME) models, we found that urinary 9-hydroxyfluorene (9-OHFlu), 2-hydroxyphenanthrene (2-OHPh), 9-hydroxyphenanthrene (9-OHPh) at lag 0 day were positively linked to miR-146a and/or miR-222. The Bayesian kernel machine regression (BKMR) analyses revealed positive overall associations of PAHs mixture at lag 0 day with miR-146a and miR-222, and urinary 9-OHFlu contributed the most. In addition, an inter-quartile range (IQR) increase in urinary 9-OHFlu at lag 0 day was associated with elevated miR-146a and miR-222 by 0.16 (95% CI: 0.02, 0.30) to 0.34 (95% CI: 0.13, 0.54). Accordingly, exposure to PAHs, especially 9-OHFlu at lag 0 day, was related to elevated arterial stiffness-related plasma miRNAs.

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多环芳烃暴露与动脉僵化相关血浆 miRNAs：一项小组研究。

人们对多环芳烃（PAHs）暴露与动脉僵化之间的内在机制知之甚少。我们开展了一项小组研究，通过三次重复调查，研究了 123 名社区成年人的个体和多环芳烃混合物摄入量与动脉僵化相关 miRNA 之间的关系。在线性混合效应（LME）模型中，我们发现滞后 0 天的尿液中 9-羟基芴（9-OHFlu）、2-羟基菲（2-OHPh）、9-羟基菲（9-OHPh）与 miR-146a 和/或 miR-222 呈正相关。贝叶斯核机器回归（BKMR）分析显示，滞后0天的多环芳烃混合物与miR-146a和miR-222总体呈正相关，其中尿液中的9-OHFlu贡献最大。此外，在滞后 0 天，尿液中 9-OHFlu 的四分位数间范围（IQR）增加与 miR-146a 和 miR-222 的升高有 0.16（95% CI：0.02，0.30）至 0.34（95% CI：0.13，0.54）的相关性。因此，暴露于多环芳烃，尤其是滞后0天的9-OHFlu，与动脉僵化相关的血浆miRNA升高有关。

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来源期刊

Environmental toxicology and pharmacology 医学-毒理学

CiteScore

7.00

自引率

4.70%

发文量

185

审稿时长

34 days

期刊介绍： Environmental Toxicology and Pharmacology publishes the results of studies concerning toxic and pharmacological effects of (human and veterinary) drugs and of environmental contaminants in animals and man. Areas of special interest are: molecular mechanisms of toxicity, biotransformation and toxicokinetics (including toxicokinetic modelling), molecular, biochemical and physiological mechanisms explaining differences in sensitivity between species and individuals, the characterisation of pathophysiological models and mechanisms involved in the development of effects and the identification of biological markers that can be used to study exposure and effects in man and animals. In addition to full length papers, short communications, full-length reviews and mini-reviews, Environmental Toxicology and Pharmacology will publish in depth assessments of special problem areas. The latter publications may exceed the length of a full length paper three to fourfold. A basic requirement is that the assessments are made under the auspices of international groups of leading experts in the fields concerned. The information examined may either consist of data that were already published, or of new data that were obtained within the framework of collaborative research programmes. Provision is also made for the acceptance of minireviews on (classes of) compounds, toxicities or mechanisms, debating recent advances in rapidly developing fields that fall within the scope of the journal.