Serum procalcitonin as a diagnostic biomarker in dogs with bacterial respiratory diseases

IF 1.2 4区农林科学 Q3 VETERINARY SCIENCES

Veterinary clinical pathology Pub Date : 2024-05-10 DOI:10.1111/vcp.13353

N. Koho, M. M. Rajamäki, S. J. Viitanen

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引用次数: 0

Abstract

Background

Procalcitonin (PCT) is a useful biomarker in humans in the identification of bacterial respiratory infections.

Objectives

The aim of this study was to investigate the utility of serum PCT measurements as a diagnostic biomarker in canine bacterial lower respiratory tract diseases.

Methods

PCT concentrations were measured in serum samples with an ELISA method previously validated for dogs. All dogs underwent thorough clinical examinations, and the diagnosis of respiratory disease was based on clinical and laboratory findings, diagnostic imaging, as well as cytology and bacterial culture of respiratory samples. PCT concentrations between different cohorts of dogs were compared with an ANOVA-model.

Results

Sixty-two privately owned dogs with respiratory diseases, 25 with bacterial pneumonia (BP), 17 with bacterial bronchitis caused by Bordetella bronchiseptica (BB), and 20 with chronic bronchitis (CB) as well as 44 healthy controls were included in the study. Serum PCT concentrations in dogs with bacterial respiratory diseases (BP mean 51.8 ng/L ± standard deviation [SD] 40.6 ng/L and BB mean 61.4 ng/L ± SD 35.3 ng/L) were not significantly different when compared with dogs with a non-bacterial respiratory disease (CB mean 89.7 ± SD 73.5 ng/L) or healthy dogs (mean 51.0 ng/L ± SD 37.5 ng/L, p > .05 in all comparisons).

Conclusions

These results indicate that despite being a valuable diagnostic, prognostic, and follow-up marker in humans with pneumonia, serum PCT concentrations are not elevated in dogs with bacterial respiratory diseases and, therefore, cannot be used as a diagnostic biomarker in dogs.

Abstract Image

查看原文本刊更多论文

将血清降钙素原作为犬细菌性呼吸道疾病的诊断生物标志物。

背景：前降钙素原（PCT）是人类识别细菌性呼吸道感染的有效生物标记物：前降钙素原（PCT）是人类识别细菌性呼吸道感染的有效生物标志物：本研究旨在调查血清 PCT 测量作为犬细菌性下呼吸道疾病诊断生物标志物的实用性：方法：采用之前已在狗身上验证过的 ELISA 方法测量血清样本中的 PCT 浓度。所有犬只都接受了全面的临床检查，呼吸道疾病的诊断基于临床和实验室检查结果、诊断性影像学以及呼吸道样本的细胞学和细菌培养。采用方差分析模型比较了不同群组犬之间的 PCT 浓度：研究共纳入了 62 只患有呼吸道疾病的私人饲养犬，其中 25 只患有细菌性肺炎（BP），17 只患有由支气管败血波氏杆菌引起的细菌性支气管炎（BB），20 只患有慢性支气管炎（CB），以及 44 只健康对照组犬。患有细菌性呼吸道疾病的犬（BP 平均 51.8 纳克/升 ± 标准差 [SD] 40.6 纳克/升，BB 平均 61.4 纳克/升 ± 标准差 35.3 纳克/升）的血清 PCT 浓度与患有非细菌性呼吸道疾病的犬（CB 平均 89.7 纳克/升 ± 标准差 73.5 纳克/升）或健康犬（平均 51.0 纳克/升 ± 标准差 37.5 纳克/升，所有比较中 P > .05）相比无显著差异：这些结果表明，尽管血清 PCT 浓度在人类肺炎患者中是一种有价值的诊断、预后和随访标志物，但在患有细菌性呼吸道疾病的狗中却不会升高，因此不能用作狗的诊断生物标志物。

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来源期刊

Veterinary clinical pathology 农林科学-兽医学

CiteScore

1.70

自引率

16.70%

发文量

133

审稿时长

18-36 weeks

期刊介绍： Veterinary Clinical Pathology is the official journal of the American Society for Veterinary Clinical Pathology (ASVCP) and the European Society of Veterinary Clinical Pathology (ESVCP). The journal''s mission is to provide an international forum for communication and discussion of scientific investigations and new developments that advance the art and science of laboratory diagnosis in animals. Veterinary Clinical Pathology welcomes original experimental research and clinical contributions involving domestic, laboratory, avian, and wildlife species in the areas of hematology, hemostasis, immunopathology, clinical chemistry, cytopathology, surgical pathology, toxicology, endocrinology, laboratory and analytical techniques, instrumentation, quality assurance, and clinical pathology education.