Associations between periodontitis and serum anti-malondialdehyde–acetaldehyde antibody concentrations in rheumatoid arthritis: A case-control study

IF 4.2 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of periodontology Pub Date : 2024-05-10 DOI:10.1002/JPER.23-0604

Joyce A. Lee, Ted R. Mikuls, Harlan R. Sayles, Geoffrey M. Thiele, Michael J. Duryee, Jeffrey B. Payne

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Abstract

Background

Malondialdehyde–acetaldehyde (MAA) adducts lead to generation of anti-MAA autoantibodies and have been independently identified in inflamed periodontal and rheumatoid arthritis (RA) tissues. This study evaluates serum samples from RA cases and osteoarthritis (OA) controls to quantify associations between periodontal clinical measures, alveolar bone loss (ABL), and anti-Porphyromonas gingivalis, anti-Prevotella intermedia, and anti-Fusobacterium nucleatum antibody concentrations with anti-MAA antibody concentrations.

Methods

Participants (n = 284 RA cases, n = 330 OA controls) underwent periodontal clinical assessments and ABL measurements. Serum immunoglobulin (Ig) A, IgG, and IgM anti-MAA and serum IgG antibacterial antibody concentrations were quantified by enzyme-linked immunosorbent assay (ELISA). Analyses utilized simple linear regression and multivariable adjusted models.

Results

No significant associations of periodontal clinical measures with serum anti-MAA were found. Moderate (p = 0.038 and p = 0.036, respectively) and high ABL (p = 0.012 and p = 0.014, respectively) in RA cases (but not in OA) were positively associated with IgG and IgM anti-MAA. Anti-P. gingivalis and anti-P. intermedia antibody concentrations were positively associated with IgA (p = 0.001 for both), IgG (p = 0.007 and p = 0.034, respectively), and IgM anti-MAA antibody concentrations (p < 0.001 and p = 0.020, respectively), while anti-F. nucleatum was positively associated with IgG anti-MAA (p = 0.042), findings that were similar across groups.

Conclusions

A positive association was demonstrated between ABL and serum IgG and IgM anti-MAA antibody concentrations that was unique to RA and not observed in OA. Serum anti-P. gingivalis, anti-P. intermedia, and anti-F. nucleatum antibody concentrations displayed significant associations with anti-MAA antibody in both groups. These findings suggest MAA may play a role in the interrelationship between the periodontium and RA.

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类风湿性关节炎患者牙周炎与血清抗丙二醛-乙醛抗体浓度之间的关系：病例对照研究。

背景：丙二醛-乙醛（MAA）加合物会导致产生抗MAA自身抗体，并已在发炎的牙周和类风湿性关节炎（RA）组织中独立发现。本研究评估了 RA 病例和骨关节炎（OA）对照组的血清样本，以量化牙周临床指标、牙槽骨损失（ABL）、抗牙龈卟啉单胞菌、抗中间前伏菌和抗核分枝杆菌抗体浓度与抗 MAA 抗体浓度之间的关联：参与者（n = 284 例 RA 病例，n = 330 例 OA 对照组）接受牙周临床评估和 ABL 测量。血清免疫球蛋白 (Ig) A、IgG 和 IgM 抗MAA 以及血清 IgG 抗菌抗体浓度通过酶联免疫吸附试验 (ELISA) 进行量化。分析采用简单线性回归和多变量调整模型：结果：未发现牙周临床指标与血清抗 MAA 有明显关联。RA病例中的中度（p = 0.038，分别为0.038和0.036）和高度ABL（p = 0.012和0.014，分别为0.012和0.014）与IgG和IgM抗MAA呈正相关。抗牙龈脓肿和抗中间型牙龈脓肿抗体浓度与 IgA（两者均为 p = 0.001）、IgG（分别为 p = 0.007 和 p = 0.034）和 IgM 抗MAA 抗体浓度呈正相关（p 结论）：ABL 与血清 IgG 和 IgM 抗MAA 抗体浓度之间呈正相关，这是 RA 所特有的，在 OA 中未观察到。两组患者的血清抗牙龈脓肿、抗中间脓肿和抗核脓肿抗体浓度均与抗 MAA 抗体有显著关联。这些研究结果表明，MAA可能在牙周和RA之间的相互关系中发挥作用。

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