von Meyenburg complexes are more frequently associated with cholangiocarcinoma.

IF 2.5 4区医学 Q2 PATHOLOGY

Journal of Clinical Pathology Pub Date : 2025-04-17 DOI:10.1136/jcp-2024-209572

Dhanpat Jain, Binny Khandakar, Pu Ni, Barton Kenney, Lihui Qin, Vikram Deshpande, Maria Isabel Fiel

{"title":"von Meyenburg complexes are more frequently associated with cholangiocarcinoma.","authors":"Dhanpat Jain, Binny Khandakar, Pu Ni, Barton Kenney, Lihui Qin, Vikram Deshpande, Maria Isabel Fiel","doi":"10.1136/jcp-2024-209572","DOIUrl":null,"url":null,"abstract":"Aim: There is some evidence that von Meyenburg complexes (VMCs) can progress to cholangiocarcinoma (CC). This study aimed to evaluate the prevalence of VMCs in CC cases.Methods: All hepatic resections and explants with intra-hepatic CC (I-CC) and hilar-CC (H-CC) from 1985 to 2020 were studied. Hepatic resections (n=68) for benign lesions or metastatic colonic carcinoma and 15 cases with cirrhosis without any cancer were used as controls.Results: A total of 118 cases of CC (88 I-CC, 30 H-CC) were identified. Of these, 61 (52%) patients had no known background liver disease, and 20 (17%) had cirrhosis. Associated liver disorders included metabolic dysfunction-associated steatohepatitis (23), chronic viral hepatitis B or C (13), biliary disease (primary or secondary sclerosing cholangitis) (8), polycystic kidney disease (6), cryptogenic cirrhosis (5) and others miscellaneous disorders (7). VMCs were present in 34 (39%) of 88 I-CC cases and 7 (23%) of 30 H-CC cases. VMCs were present within the tumour (20 cases), outside the cancer (21 cases) or at both locations (10 cases). VMCs with dysplasia/carcinoma in situ were seen in 19 of 41 (46%) cases with CC and VMCs. In addition, bile duct adenomas were identified in 6 (5%) of CC. 7% of controls showed the presence of VMCs compared with 35% of CC cases (p<0.05).Conclusions: VMCs are seen far more frequently in patients with CC than in the control group. The findings support the hypothesis that VMCs could represent a precursor of CC or a marker for a higher risk of developing CC.","PeriodicalId":15391,"journal":{"name":"Journal of Clinical Pathology","volume":" ","pages":"300-306"},"PeriodicalIF":2.5000,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Clinical Pathology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1136/jcp-2024-209572","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PATHOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Aim: There is some evidence that von Meyenburg complexes (VMCs) can progress to cholangiocarcinoma (CC). This study aimed to evaluate the prevalence of VMCs in CC cases.

Methods: All hepatic resections and explants with intra-hepatic CC (I-CC) and hilar-CC (H-CC) from 1985 to 2020 were studied. Hepatic resections (n=68) for benign lesions or metastatic colonic carcinoma and 15 cases with cirrhosis without any cancer were used as controls.

Results: A total of 118 cases of CC (88 I-CC, 30 H-CC) were identified. Of these, 61 (52%) patients had no known background liver disease, and 20 (17%) had cirrhosis. Associated liver disorders included metabolic dysfunction-associated steatohepatitis (23), chronic viral hepatitis B or C (13), biliary disease (primary or secondary sclerosing cholangitis) (8), polycystic kidney disease (6), cryptogenic cirrhosis (5) and others miscellaneous disorders (7). VMCs were present in 34 (39%) of 88 I-CC cases and 7 (23%) of 30 H-CC cases. VMCs were present within the tumour (20 cases), outside the cancer (21 cases) or at both locations (10 cases). VMCs with dysplasia/carcinoma in situ were seen in 19 of 41 (46%) cases with CC and VMCs. In addition, bile duct adenomas were identified in 6 (5%) of CC. 7% of controls showed the presence of VMCs compared with 35% of CC cases (p<0.05).

Conclusions: VMCs are seen far more frequently in patients with CC than in the control group. The findings support the hypothesis that VMCs could represent a precursor of CC or a marker for a higher risk of developing CC.

查看原文本刊更多论文

von Meyenburg复合体更常见于胆管癌。

目的：有证据表明，von Meyenburg复合体（VMC）可发展为胆管癌（CC）。本研究旨在评估 VMC 在 CC 病例中的发病率：研究对象为1985年至2020年期间所有肝切除和肝内CC（I-CC）和肝门CC（H-CC）病例。以良性病变或转移性结肠癌的肝切除术（68 例）和 15 例无任何癌症的肝硬化病例作为对照：结果：共发现 118 例 CC（88 例 I-CC 和 30 例 H-CC）。其中，61 例（52%）患者没有已知的背景肝病，20 例（17%）患有肝硬化。伴发的肝脏疾病包括代谢功能障碍相关性脂肪性肝炎（23 例）、慢性乙型或丙型病毒性肝炎（13 例）、胆道疾病（原发性或继发性硬化性胆管炎）（8 例）、多囊肾（6 例）、隐源性肝硬化（5 例）和其他杂症（7 例）。在 88 例 I-CC 病例中，有 34 例（39%）存在血管内皮细胞；在 30 例 H-CC 病例中，有 7 例（23%）存在血管内皮细胞。血管内皮细胞出现在肿瘤内（20 例）、肿瘤外（21 例）或两个部位（10 例）。在 41 例有 CC 和 VMC 的病例中，19 例（46%）的 VMC 伴有发育不良/原位癌。此外，在 6 例（5%）CC 患者中发现了胆管腺瘤。7%的对照组病例出现 VMCs，而 35% 的 CC 病例出现 VMCs：VMC在CC患者中的出现率远远高于对照组。研究结果支持以下假设：VMC可能是CC的前兆，也可能是CC高风险的标志。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Clinical Pathology 医学-病理学

CiteScore

7.80

自引率

2.90%

发文量

113

审稿时长

3-8 weeks

期刊介绍： Journal of Clinical Pathology is a leading international journal covering all aspects of pathology. Diagnostic and research areas covered include histopathology, virology, haematology, microbiology, cytopathology, chemical pathology, molecular pathology, forensic pathology, dermatopathology, neuropathology and immunopathology. Each issue contains Reviews, Original articles, Short reports, Correspondence and more.