Unveiling the intricacies of bone homeostasis: Epigenetic regulation, extracellular vesicles, and angiogenesis integration

Célio Junior da Costa Fernandes
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引用次数: 0

Abstract

Bone homeostasis is a complex process involving the coordinated actions of various bone cells and their interactions with the surrounding microenvironment. Epigenetic regulation, specifically through DNA methylation, histone acetylation, microRNAs, and long non-coding RNAs, has been identified as a crucial factor in maintaining bone health. Furthermore, the interplay between bone cells and angiogenesis, the process of forming new blood vessels, plays a critical role in maintaining bone health. Epigenetic factors have been found to regulate angiogenesis in bone tissue. Extracellular vesicles derived from different cell types, such as osteoblasts, endothelial cells, and mesenchymal stem cells, are also important in bone homeostasis. These vesicles transport bioactive molecules, including microRNAs, growth factors, and cytokines, which regulate angiogenesis and influence the function of bone cells. Understanding the epigenetic control of gene expression and the role of extracellular vesicles in bone homeostasis has significant implications for the development of therapeutic strategies for bone disorders. This knowledge is particularly valuable in the context of aging, metabolic disorders, and pathological disruptions of bone homeostasis.

揭开骨平衡的神秘面纱:表观遗传调控、细胞外囊泡和血管生成整合
骨平衡是一个复杂的过程,涉及各种骨细胞的协调作用及其与周围微环境的相互作用。表观遗传调控,特别是通过 DNA 甲基化、组蛋白乙酰化、microRNA 和长非编码 RNA 进行的调控,已被确定为维持骨骼健康的关键因素。此外,骨细胞与血管生成(形成新血管的过程)之间的相互作用在维持骨骼健康方面起着至关重要的作用。研究发现,表观遗传因素可调节骨组织中的血管生成。来自不同类型细胞(如成骨细胞、内皮细胞和间充质干细胞)的细胞外囊泡对骨平衡也很重要。这些囊泡运输生物活性分子,包括微核糖核酸、生长因子和细胞因子,它们能调节血管生成并影响骨细胞的功能。了解基因表达的表观遗传学控制以及细胞外囊泡在骨稳态中的作用,对开发骨病治疗策略具有重要意义。这些知识对于衰老、代谢紊乱和骨平衡的病理性破坏尤为重要。
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来源期刊
Extracellular vesicle
Extracellular vesicle Biochemistry, Genetics and Molecular Biology (General)
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