Association between decreased cord blood inter-alpha inhibitor levels and neonatal encephalopathy at birth

IF 2.2 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Early human development Pub Date : 2024-05-07 DOI:10.1016/j.earlhumdev.2024.106036

Lynn Bitar , Barbara S. Stonestreet , Yow-Pin Lim , Joseph Qiu , Xiaodi Chen , Imran N. Mir , Lina F. Chalak

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引用次数: 0

Abstract

Background

Inter-alpha inhibitor proteins (IAIPs) are structurally related proteins found in the systemic circulation with immunomodulatory anti-inflammatory properties. Reduced levels are found in inflammatory related conditions including sepsis and necrotizing enterocolitis, and in neonatal rodents after exposure to hypoxia ischemia. In the current study, cord blood IAIP levels were measured in neonates with and without exposure to hypoxic-ischemic encephalopathy (HIE).

Methods

This is a prospective cohort study including infants born ≥36 weeks over a one-year period. Term pregnancies were divided into two groups: a “reference control” (uncomplicated term deliveries), and “moderate to severe HIE” (qualifying for therapeutic hypothermia). IAIPs were quantified using a sensitive ELISA on the cord blood samples.

Results

The study included 57 newborns: Reference control group (n = 13) and moderate/severe HIE group (n = 44). Measurement of IAIP cord blood concentrations in moderate to severe HIE group [278.2 (138.0, 366.0) μg/ml] revealed significantly lower IAIP concentrations compared with the control group [418.6 (384.5, 445.0) μg/ml] (p = 0.002).

Conclusions

These findings suggest a potential role for IAIPs as indicators of neonates at risk for HIE. IAIP levels could have diagnostic implications in the management of HIE. Future research is required to explore the relationship between HIE and IAIPs as biomarkers for disease severity.

Category of study

Translational.

查看原文本刊更多论文

脐带血中α间抑制剂水平降低与新生儿出生时脑病之间的关系

背景α间抑制蛋白（IAIPs）是一种结构相关的蛋白质，存在于全身循环中，具有免疫调节抗炎特性。在败血症和坏死性小肠结肠炎等炎症相关疾病中，以及在新生啮齿动物缺氧缺血后，都会发现IAIPs水平降低。本研究测量了缺氧缺血性脑病（HIE）新生儿和未患缺氧缺血性脑病新生儿的脐带血 IAIP 水平。足月妊娠分为两组："参照对照组"（无并发症的足月分娩）和 "中度至重度 HIE"（符合治疗性低温条件）。采用敏感的 ELISA 方法对脐带血样本中的 IAIPs 进行定量分析：参考对照组（13 例）和中度/重度 HIE 组（44 例）。与对照组[418.6 (384.5, 445.0) μg/ml]相比，中度至重度 HIE 组的 IAIP 脐带血浓度[278.2 (138.0, 366.0) μg/ml]测量结果显示明显较低 (p = 0.002)。IAIP水平可能对HIE的管理具有诊断意义。未来的研究需要探索 HIE 与作为疾病严重程度生物标志物的 IAIPs 之间的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Early human development 医学-妇产科学

CiteScore

4.40

自引率

4.00%

发文量

100

审稿时长

46 days

期刊介绍： Established as an authoritative, highly cited voice on early human development, Early Human Development provides a unique opportunity for researchers and clinicians to bridge the communication gap between disciplines. Creating a forum for the productive exchange of ideas concerning early human growth and development, the journal publishes original research and clinical papers with particular emphasis on the continuum between fetal life and the perinatal period; aspects of postnatal growth influenced by early events; and the safeguarding of the quality of human survival. The first comprehensive and interdisciplinary journal in this area of growing importance, Early Human Development offers pertinent contributions to the following subject areas: Fetology; perinatology; pediatrics; growth and development; obstetrics; reproduction and fertility; epidemiology; behavioural sciences; nutrition and metabolism; teratology; neurology; brain biology; developmental psychology and screening.