Rare-variant association study unveils the Achilles' heel for HCC.

IF 11.1 Q1 CELL BIOLOGY
Yin Wang, Ying Wai Chan
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引用次数: 0

Abstract

In this issue of Cell Genomics, Wang, Liu, Zuo, Wang, et al.1 investigate rare variants in hepatocellular carcinoma (HCC) by performing the first rare-variant association study (RVAS) in a Chinese population cohort. It uncovers BRCAness phenotypes associated with the NRDE2-p.N377I variant, suggesting PARP inhibitors as a promising therapeutic approach for certain HCC patients.

罕见变异关联研究揭示了 HCC 的致命弱点。
在本期《细胞基因组学》(Cell Genomics)杂志上,Wang、Liu、Zuo、Wang 等人1 首次在中国人群队列中开展了罕见变异关联研究(RVAS),研究了肝细胞癌(HCC)中的罕见变异。该研究发现了与 NRDE2-p.N377I 变异相关的 BRCAness 表型,提示 PARP 抑制剂是治疗某些 HCC 患者的有效方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
7.10
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