Three new nonenes from culture broth of marine-derived fungus Albifimbria verrucaria and their cytotoxic and anti-viral activities

IF 2.1 4区医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Journal of Antibiotics Pub Date : 2024-05-09 DOI:10.1038/s41429-024-00735-1

Young-Hee Kim, Dae-Cheol Choi, Dae-Won Ki, Yeong-Seon Won, Seung-Jae Lee, Ji-Yul Kim, In-Kyoung Lee, Bong-Sik Yun

引用次数: 0

Abstract

Three new nonenes, verrucanonenes A‒C (1‒3), were isolated from culture broth of marine-derived fungus Albifimbria verrucaria. These compounds were isolated using silica gel column chromatography, reversed-phase medium pressure liquid chromatography, Sephadex LH-20 column chromatography, and preparative HPLC. Their structures were determined using a spectroscopic method. Cytotoxicities of these isolated compounds to A549, DU145, HCT116, and HT1080 cancer cell lines were assessed. Compounds 1‒3 exhibited cytotoxicities to DU145 cancer cell line, with IC50 values of 23.4, 28.6, and 20.1 µM, respectively. Compound 2 decreased H1N1-induced cytopathic effects on MDCK cells in a dose-dependent manner.

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从海洋源真菌 Albifimbria verrucaria 的培养液中提取的三种新壬烯及其细胞毒性和抗病毒活性。

从海洋源真菌 Albifimbria verrucaria 的培养液中分离出了三种新的壬烯类化合物--疣螈烯 A-C (1-3)。采用硅胶柱色谱法、反相中压液相色谱法、Sephadex LH-20 柱色谱法和制备型高效液相色谱法分离了这些化合物。采用光谱法确定了它们的结构。评估了这些分离化合物对 A549、DU145、HCT116 和 HT1080 癌细胞株的细胞毒性。化合物 1-3 对 DU145 癌细胞株具有细胞毒性，IC50 值分别为 23.4、28.6 和 20.1 µM。化合物 2 以剂量依赖的方式降低了 H1N1 诱导的细胞病理效应对 MDCK 细胞的影响。

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来源期刊

Journal of Antibiotics 医学-免疫学

CiteScore

6.60

自引率

3.00%

发文量

审稿时长

1 months

期刊介绍： The Journal of Antibiotics seeks to promote research on antibiotics and related types of biologically active substances and publishes Articles, Review Articles, Brief Communication, Correspondence and other specially commissioned reports. The Journal of Antibiotics accepts papers on biochemical, chemical, microbiological and pharmacological studies. However, studies regarding human therapy do not fall under the journal’s scope. Contributions regarding recently discovered antibiotics and biologically active microbial products are particularly encouraged. Topics of particular interest within the journal''s scope include, but are not limited to, those listed below: Discovery of new antibiotics and related types of biologically active substances Production, isolation, characterization, structural elucidation, chemical synthesis and derivatization, biological activities, mechanisms of action, and structure-activity relationships of antibiotics and related types of biologically active substances Biosynthesis, bioconversion, taxonomy and genetic studies on producing microorganisms, as well as improvement of production of antibiotics and related types of biologically active substances Novel physical, chemical, biochemical, microbiological or pharmacological methods for detection, assay, determination, structural elucidation and evaluation of antibiotics and related types of biologically active substances Newly found properties, mechanisms of action and resistance-development of antibiotics and related types of biologically active substances.