Analysis and Reporting of Randomized Trials in Cleft Palate Surgery: Learning from the Timing of Primary Surgery (TOPS) Trial.

IF 1.1 4区医学 Q2 Dentistry

Cleft Palate-Craniofacial Journal Pub Date : 2024-05-09 DOI:10.1177/10556656241253949

Matthew Fell, Ginette Phippen, Stephanie van Eeden, David Chong, Marc C Swan, Simon van Eeden, John B Carlin

引用次数: 0

Abstract

The Timing of Primary Surgery (TOPS) trial was published August 2023 in the New England Journal of Medicine and is a milestone achievement for a study focused on cleft palate. Due to the complexity of outcome reporting in cleft and the rarity of such comparative trials, TOPS presents a useful opportunity to critically review the design, analysis and reporting strategies utilised. This perspective article focused on the inclusion of participants, the choice of the primary outcome measure and the analysis of ordinal data within the trial. Considerations for future comparative studies in cleft care are discussed.

查看原文本刊更多论文

腭裂手术随机试验的分析与报告：从初级手术时机（TOPS）试验中学习。

初次手术时机（TOPS）试验于 2023 年 8 月发表在《新英格兰医学杂志》上，对于一项专注于腭裂的研究来说，这是一项里程碑式的成就。由于腭裂结果报告的复杂性以及此类比较试验的罕见性，TOPS 为我们提供了一个有益的机会，对所采用的设计、分析和报告策略进行批判性回顾。这篇透视文章的重点是试验中参与者的纳入、主要结果测量指标的选择以及序数数据的分析。文章还讨论了今后进行裂隙护理比较研究的注意事项。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Cleft Palate-Craniofacial Journal DENTISTRY, ORAL SURGERY & MEDICINE-SURGERY

CiteScore

2.20

自引率

36.40%

发文量

审稿时长

4-8 weeks

期刊介绍： The Cleft Palate-Craniofacial Journal (CPCJ) is the premiere peer-reviewed, interdisciplinary, international journal dedicated to current research on etiology, prevention, diagnosis, and treatment in all areas pertaining to craniofacial anomalies. CPCJ reports on basic science and clinical research aimed at better elucidating the pathogenesis, pathology, and optimal methods of treatment of cleft and craniofacial anomalies. The journal strives to foster communication and cooperation among professionals from all specialties.