Memory in female adolescents with congenital adrenal hyperplasia due to 21-hydroxylase deficiency.

IF 3 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Endocrine Pub Date : 2024-09-01 Epub Date: 2024-05-10 DOI:10.1007/s12020-024-03806-3
Tania M Espinosa Reyes, Dainy Cordero Martín, Miguel Ángel Álvarez, Henrik Falhammar
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引用次数: 0

Abstract

Introduction: In females with congenital adrenal hyperplasia (CAH), the influence of hyperandrogenism and glucocorticoid supplementation on neurocognition is controversial.

Objectives: To identify possible differences in visual working memory and verbal memory in adolescent girls with CAH due to 21-hydroxylase deficiency and matched controls. Moreover, to study if any relationship between variables associated with CAH and the scores of the selected memory tests was present.

Material and methods: In total 39 individuals were studied, female adolescents with CAH and age and pubertal stage matched healthy male and female controls (13 in each group). Sociodemographic, clinical, hormonal, and neurocognitive variables were explored. In female adolescents with CAH, variables related to the disease (age at diagnosis, clinical form, time since diagnosis, and glucocorticoid doses) were correlated with the scores obtained for neurocognitive variables.

Results: The mean age was 13.9 ± 3.3 years. In female adolescents with CAH the results were worse compared to controls in Free Recall (p = 0.039) and in Visual Memory Span score (p = 0.016). Age at diagnosis was negatively correlated to number of hits (p = 0.04), number recalled backward (p = 0.03), Visual Memory Span test score (p = 0.04) and Total Free Recall (p = 0.04), i.e., memory was worse with later diagnosis.

Conclusions: Female adolescents with CAH had worse visual working memory compared to matched controls, but not in verbal memory. Age at diagnosis was negatively associated with the memory tests.

因缺乏 21-羟化酶而患有先天性肾上腺皮质增生症的女性青少年的记忆力。
简介:在先天性肾上腺皮质增生症(CAH)女性患者中,高雄激素和糖皮质激素补充对神经认知的影响存在争议:在先天性肾上腺皮质增生症(CAH)女性患者中,高雄激素和糖皮质激素补充对神经认知的影响存在争议:目的:确定因缺乏21-羟化酶而患有先天性肾上腺皮质增生症(CAH)的少女与匹配对照组在视觉工作记忆和言语记忆方面可能存在的差异。此外,研究与 CAH 相关的变量与所选记忆测试得分之间是否存在任何关系:研究对象共 39 人,包括患有 CAH 的女性青少年以及年龄和青春期阶段相匹配的健康男性和女性对照组(每组 13 人)。研究探讨了社会人口学、临床、激素和神经认知变量。在患有CAH的女性青少年中,与疾病相关的变量(诊断年龄、临床形式、诊断后时间和糖皮质激素剂量)与神经认知变量的得分相关:平均年龄为(13.9 ± 3.3)岁。与对照组相比,患有CAH的女性青少年在自由回忆(p = 0.039)和视觉记忆跨度(p = 0.016)方面的成绩较差。确诊年龄与命中数(p = 0.04)、向后回忆数(p = 0.03)、视觉记忆跨度测试得分(p = 0.04)和自由回忆总分(p = 0.04)呈负相关,即确诊时间越晚,记忆力越差:结论:与匹配的对照组相比,患有CAH的女性青少年的视觉工作记忆能力较差,但言语记忆能力并不差。诊断年龄与记忆测试呈负相关。
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来源期刊
Endocrine
Endocrine ENDOCRINOLOGY & METABOLISM-
CiteScore
6.50
自引率
5.40%
发文量
295
审稿时长
1.5 months
期刊介绍: Well-established as a major journal in today’s rapidly advancing experimental and clinical research areas, Endocrine publishes original articles devoted to basic (including molecular, cellular and physiological studies), translational and clinical research in all the different fields of endocrinology and metabolism. Articles will be accepted based on peer-reviews, priority, and editorial decision. Invited reviews, mini-reviews and viewpoints on relevant pathophysiological and clinical topics, as well as Editorials on articles appearing in the Journal, are published. Unsolicited Editorials will be evaluated by the editorial team. Outcomes of scientific meetings, as well as guidelines and position statements, may be submitted. The Journal also considers special feature articles in the field of endocrine genetics and epigenetics, as well as articles devoted to novel methods and techniques in endocrinology. Endocrine covers controversial, clinical endocrine issues. Meta-analyses on endocrine and metabolic topics are also accepted. Descriptions of single clinical cases and/or small patients studies are not published unless of exceptional interest. However, reports of novel imaging studies and endocrine side effects in single patients may be considered. Research letters and letters to the editor related or unrelated to recently published articles can be submitted. Endocrine covers leading topics in endocrinology such as neuroendocrinology, pituitary and hypothalamic peptides, thyroid physiological and clinical aspects, bone and mineral metabolism and osteoporosis, obesity, lipid and energy metabolism and food intake control, insulin, Type 1 and Type 2 diabetes, hormones of male and female reproduction, adrenal diseases pediatric and geriatric endocrinology, endocrine hypertension and endocrine oncology.
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