A Mesenchymal stem cell Aging Framework, from Mechanisms to Strategies.

IF 4.5 3区医学 Q2 CELL & TISSUE ENGINEERING

Stem Cell Reviews and Reports Pub Date : 2024-08-01 Epub Date: 2024-05-10 DOI:10.1007/s12015-024-10732-4

Hongqing Zhao, Houming Zhao, Shuaifei Ji

引用次数: 0

Abstract

Mesenchymal stem cells (MSCs) are extensively researched for therapeutic applications in tissue engineering and show significant potential for clinical use. Intrinsic or extrinsic factors causing senescence may lead to reduced proliferation, aberrant differentiation, weakened immunoregulation, and increased inflammation, ultimately limiting the potential of MSCs. It is crucial to comprehend the molecular pathways and internal processes responsible for the decline in MSC function due to senescence in order to devise innovative approaches for rejuvenating senescent MSCs and enhancing MSC treatment. We investigate the main molecular processes involved in senescence, aiming to provide a thorough understanding of senescence-related issues in MSCs. Additionally, we analyze the most recent advancements in cutting-edge approaches to combat MSC senescence based on current research. We are curious whether the aging process of stem cells results in a permanent "memory" and if cellular reprogramming may potentially revert the aging epigenome to a more youthful state.

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间充质干细胞老化框架，从机制到战略。

间充质干细胞（MSCs）被广泛研究用于组织工程的治疗，并显示出巨大的临床应用潜力。引起衰老的内在或外在因素可能导致增殖减少、分化异常、免疫调节减弱和炎症增加，最终限制间充质干细胞的潜力。为了设计出使衰老的间充质干细胞恢复活力并提高间充质干细胞治疗效果的创新方法，理解导致间充质干细胞功能因衰老而下降的分子途径和内部过程至关重要。我们研究了衰老涉及的主要分子过程，旨在提供对间叶干细胞衰老相关问题的透彻理解。此外，我们还根据目前的研究分析了对抗间充质干细胞衰老的前沿方法的最新进展。我们很好奇干细胞的衰老过程是否会导致永久性的 "记忆"，以及细胞重编程是否有可能将衰老的表观基因组恢复到更年轻的状态。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Stem Cell Reviews and Reports 医学-细胞生物学

CiteScore

9.30

自引率

4.20%

发文量

审稿时长

3 months

期刊介绍： The purpose of Stem Cell Reviews and Reports is to cover contemporary and emerging areas in stem cell research and regenerative medicine. The journal will consider for publication: i) solicited or unsolicited reviews of topical areas of stem cell biology that highlight, critique and synthesize recent important findings in the field. ii) full length and short reports presenting original experimental work. iii) translational stem cell studies describing results of clinical trials using stem cells as therapeutics. iv) papers focused on diseases of stem cells. v) hypothesis and commentary articles as opinion-based pieces in which authors can propose a new theory, interpretation of a controversial area in stem cell biology, or a stem cell biology question or paradigm. These articles contain more speculation than reviews, but they should be based on solid rationale. vi) protocols as peer-reviewed procedures that provide step-by-step descriptions, outlined in sufficient detail, so that both experts and novices can apply them to their own research. vii) letters to the editor and correspondence. In order to facilitate this exchange of scientific information and exciting novel ideas, the journal has created five thematic sections, focusing on: i) the role of adult stem cells in tissue regeneration; ii) progress in research on induced pluripotent stem cells, embryonic stem cells and mechanism governing embryogenesis and tissue development; iii) the role of microenvironment and extracellular microvesicles in directing the fate of stem cells; iv) mechanisms of stem cell trafficking, stem cell mobilization and homing with special emphasis on hematopoiesis; v) the role of stem cells in aging processes and cancerogenesis.