Norepinephrine may promote the progression of Fusobacterium nucleatum related colorectal cancer via quorum sensing signalling.

IF 5.5 1区农林科学 Q1 IMMUNOLOGY

Virulence Pub Date : 2024-12-01 Epub Date: 2024-05-09 DOI:10.1080/21505594.2024.2350904

Xinhao Du, Zhenzhen Tang, Li Yan, Ling Zhang, Qiao Zheng, Xianghao Zeng, Qing Hu, Qian Tian, Lanfan Liang, Xinyu Zhao, Jun Li, Ming Zhao, Xiangsheng Fu

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Abstract

Fusobacterium nucleatum (F. nucleatum) is closely correlated with tumorigenesis in colorectal cancer (CRC). We aimed to investigate the effects of host norepinephrine on the carcinogenicity of F. nucleatum in CRC and reveal the underlying mechanism. The results revealed that both norepinephrine and bacterial quorum sensing (QS) molecule auto-inducer-2 (AI-2) were positively associated with the progression of F. nucleatum related CRC (p < 0.01). In vitro studies, norepinephrine induced upregulation of QS-associated genes and promoted the virulence and proliferation of F. nucleatum. Moreover, chronic stress significantly increased the colon tumour burden of Apc^Min/+ mice infected with F. nucleatum (p < 0.01), which was decreased by a catecholamine inhibitor (p < 0.001). Our findings suggest that stress-induced norepinephrine may promote the progression of F. nucleatum related CRC via bacterial QS signalling. These preliminary data provide a novel strategy for the management of pathogenic bacteria by targeting host hormones-bacterial QS inter-kingdom signalling.

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去甲肾上腺素可通过法定人数感应信号促进与核酸镰刀菌相关的结直肠癌的进展。

核叉杆菌（F. nucleatum）与结直肠癌（CRC）的肿瘤发生密切相关。我们旨在研究宿主去甲肾上腺素对核分枝杆菌在 CRC 中致癌性的影响，并揭示其潜在机制。结果发现，去甲肾上腺素和细菌法定量传感（QS）分子自动诱导因子-2（AI-2）均与F. nucleatum相关CRC的进展呈正相关（p 在体外研究中，去甲肾上腺素诱导QS相关基因上调，促进F. nucleatum的毒力和增殖。此外，慢性应激通过细菌 QS 信号传导，明显增加了感染 F. nucleatum 的 ApcMin/+ 小鼠的结肠肿瘤负荷（p p F. nucleatum related CRC）。这些初步数据为通过靶向宿主激素-细菌 QS 部门间信号来管理病原菌提供了一种新策略。

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来源期刊

Virulence IMMUNOLOGY-MICROBIOLOGY

CiteScore

9.20

自引率

1.90%

发文量

123

审稿时长

6-12 weeks

期刊介绍： Virulence is a fully open access peer-reviewed journal. All articles will (if accepted) be available for anyone to read anywhere, at any time immediately on publication. Virulence is the first international peer-reviewed journal of its kind to focus exclusively on microbial pathogenicity, the infection process and host-pathogen interactions. To address the new infectious challenges, emerging infectious agents and antimicrobial resistance, there is a clear need for interdisciplinary research.