Akinetic mutism and gait disturbance in a patient with delayed post-hypoxic leukoencephalopathy.

IF 0.6 4区医学 Q4 CLINICAL NEUROLOGY

Neurocase Pub Date : 2024-02-01 Epub Date: 2024-05-09 DOI:10.1080/13554794.2024.2353125

Sung Ho Jang, Hyeok Gyu Kwon

引用次数: 0

Abstract

We report on a patient with delayed post-hypoxic leukoencephalopathy (DPHL) who showed akinetic mutism and gait disturbance, neural injuries that were demonstrated on diffusion tensor tractography (DTT). A patient was exposed to carbon monoxide (CO) and rapidly recovered; however, two weeks after onset, he began to show cognitive impairment and gait disturbance. At six weeks after CO exposure, he showed akinetic mutism and gait inability. DTT at 6-weeks post-exposure showed discontinuations in neural connectivities of the caudate nucleus to the medial prefrontal and orbitofrontal cortex in both hemispheres. In addition, the corticoreticulospinal tract revealed severe thinning in both hemispheres.

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一名迟发性缺氧后白质脑病患者的动觉缄默症和步态障碍。

我们报告了一名迟发性缺氧后白质脑病（DPHL）患者的情况，该患者表现出运动性缄默症和步态障碍，弥散张量束成像（DTT）显示出神经损伤。一名患者接触一氧化碳（CO）后迅速康复，但在发病两周后开始出现认知障碍和步态障碍。接触一氧化碳六周后，他出现了运动性缄默症和步态障碍。暴露后 6 周的 DTT 显示，尾状核与两半球内侧前额叶和眶额叶皮层的神经连接中断。此外，皮质脊髓束在两个半球都显示出严重变薄。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurocase 医学-精神病学

CiteScore

1.40

自引率

12.50%

发文量

审稿时长

6-12 weeks

期刊介绍： Neurocase is a rapid response journal of case studies and innovative group studies in neuropsychology, neuropsychiatry and behavioral neurology that speak to the neural basis of cognition. Four types of manuscript are considered for publication: single case investigations that bear directly on issues of relevance to theoretical issues or brain-behavior relationships; group studies of subjects with brain dysfunction that address issues relevant to the understanding of human cognition; reviews of important topics in the domains of neuropsychology, neuropsychiatry and behavioral neurology; and brief reports (up to 2500 words) that replicate previous reports dealing with issues of considerable significance. Of particular interest are investigations that include precise anatomical localization of lesions or neural activity via imaging or other techniques, as well as studies of patients with neurodegenerative diseases, since these diseases are becoming more common as our population ages. Topic reviews are included in most issues.