SARS-CoV-2 prevalence in wildlife 2020–2022: a worldwide systematic review and meta-analysis

IF 2.6 4区医学 Q3 IMMUNOLOGY

Microbes and Infection Pub Date : 2024-07-01 DOI:10.1016/j.micinf.2024.105350

Xue-Yao Yang, Jing-Shu Huang, Qing-Long Gong, Jin-Mei Sun, Yan-Jin Li, Bing Liu, Yu-Meng Zhang, Chun-Wei Shi, Gui-Lian Yang, Wen-Tao Yang, Chun-Feng Wang

{"title":"SARS-CoV-2 prevalence in wildlife 2020–2022: a worldwide systematic review and meta-analysis","authors":"Xue-Yao Yang, Jing-Shu Huang, Qing-Long Gong, Jin-Mei Sun, Yan-Jin Li, Bing Liu, Yu-Meng Zhang, Chun-Wei Shi, Gui-Lian Yang, Wen-Tao Yang, Chun-Feng Wang","doi":"10.1016/j.micinf.2024.105350","DOIUrl":null,"url":null,"abstract":"<div><p>The widespread transmission of SARS-CoV-2 in humans poses a serious threat to public health security, and a growing number of studies have discovered that SARS-CoV-2 infection in wildlife and mutate over time. This article mainly reports the first systematic review and meta-analysis of the prevalence of SARS-CoV-2 in wildlife. The pooled prevalence of the 29 included articles was calculated by us using a random effects model (22.9%) with a high heterogeneity (I<sup>2</sup> = 98.7%, p = 0.00). Subgroup analysis and univariate regression analysis found potential risk factors contributing to heterogeneity were country, wildlife species, sample type, longitude, and precipitation. In addition, the prevalence of SARS-CoV-2 in wildlife increased gradually over time. Consequently, it is necessary to comprehensively analyze the risk factors of SARS-CoV-2 infection in wildlife and develop effective control policies, as well as to monitor the mutation of SARS-CoV-2 in wildlife at all times to reduce the risk of SARS-CoV-2 transmission among different species.</p></div>","PeriodicalId":18497,"journal":{"name":"Microbes and Infection","volume":null,"pages":null},"PeriodicalIF":2.6000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Microbes and Infection","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1286457924000807","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"IMMUNOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

The widespread transmission of SARS-CoV-2 in humans poses a serious threat to public health security, and a growing number of studies have discovered that SARS-CoV-2 infection in wildlife and mutate over time. This article mainly reports the first systematic review and meta-analysis of the prevalence of SARS-CoV-2 in wildlife. The pooled prevalence of the 29 included articles was calculated by us using a random effects model (22.9%) with a high heterogeneity (I² = 98.7%, p = 0.00). Subgroup analysis and univariate regression analysis found potential risk factors contributing to heterogeneity were country, wildlife species, sample type, longitude, and precipitation. In addition, the prevalence of SARS-CoV-2 in wildlife increased gradually over time. Consequently, it is necessary to comprehensively analyze the risk factors of SARS-CoV-2 infection in wildlife and develop effective control policies, as well as to monitor the mutation of SARS-CoV-2 in wildlife at all times to reduce the risk of SARS-CoV-2 transmission among different species.

查看原文本刊更多论文

2020-2022 年野生动物中的 SARS-CoV-2 流行率：全球系统回顾和荟萃分析。

SARS-CoV-2 在人类中的广泛传播对公共卫生安全构成了严重威胁，越来越多的研究发现，野生动物中的 SARS-CoV-2 感染会随着时间的推移而发生变异。本文主要报告了首次关于野生动物中 SARS-CoV-2 流行情况的系统回顾和荟萃分析。我们使用随机效应模型计算了 29 篇纳入文章的汇总流行率（22.9%），异质性较高（I2=98.7%，P=0.00）。亚组分析和单变量回归分析发现，导致异质性的潜在风险因素包括国家、野生动物种类、样本类型、经度和降水量。此外，SARS-CoV-2 在野生动物中的流行率随着时间的推移逐渐增加。因此，有必要全面分析野生动物感染SARS-CoV-2的风险因素，制定有效的控制政策，并随时监测野生动物体内SARS-CoV-2的变异情况，以降低SARS-CoV-2在不同物种间传播的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Microbes and Infection 医学-病毒学

CiteScore

12.60

自引率

1.70%

发文量

审稿时长

40 days

期刊介绍： Microbes and Infection publishes 10 peer-reviewed issues per year in all fields of infection and immunity, covering the different levels of host-microbe interactions, and in particular: the molecular biology and cell biology of the crosstalk between hosts (human and model organisms) and microbes (viruses, bacteria, parasites and fungi), including molecular virulence and evasion mechanisms. the immune response to infection, including pathogenesis and host susceptibility. emerging human infectious diseases. systems immunology. molecular epidemiology/genetics of host pathogen interactions. microbiota and host "interactions". vaccine development, including novel strategies and adjuvants. Clinical studies, accounts of clinical trials and biomarker studies in infectious diseases are within the scope of the journal. Microbes and Infection publishes articles on human pathogens or pathogens of model systems. However, articles on other microbes can be published if they contribute to our understanding of basic mechanisms of host-pathogen interactions. Purely descriptive and preliminary studies are discouraged.