Genome sequence of pan drug-resistant enteroaggregative Escherichia coli belonging to ST38 clone from India, an emerging EAEC/UPEC hybrid pathotype

IF 1.4 4区医学 Q4 IMMUNOLOGY

Indian Journal of Medical Microbiology Pub Date : 2024-05-01 DOI:10.1016/j.ijmmb.2024.100606

Harpreet Kaur , Inderjit Singh , Vinay Modgil , Nisha Singh, Balvinder Mohan, Neelam Taneja

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Abstract

Here, we report the genomic characterization of a pan drug-resistant (PDR) enteroaggregative Escherichia coli (EAEC) isolated from an immunocompromised infant who had diarrhea. The isolate belonged to the sequence type (ST) 38, which is a known enteroaggregative Escherichia coli (EAEC)/uropathogenic Escherichia coli (UPEC) hybrid strain having multi-drug resistance (MDR). The strain carried genes encoding multiple resistances to carbapenems, third-generation cephalosporins, polymyxin, fluoroquinolones, aminoglycosides, fosfomycin, nitrofurantoin, sulphonamides, and multiple efflux pump genes. Interspecies horizontal transfer, inter-strain, and clonal spread of these resistances to commensals and pathogens will be worrisome. We are concerned about the spread of such PDR strains. The genomic characterization of such strains will be useful in understanding the genetic makeup of EAEC/UPEC hybrid strains and developing new vaccines/diagnostics and therapeutics.

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印度一种新出现的 EAEC/UPEC 混合病型--属于 ST38 克隆的泛耐药肠道聚集性大肠杆菌的基因组序列。

在此，我们报告了从一名腹泻的免疫力低下婴儿体内分离出的泛耐药（PDR）肠道聚集性大肠埃希菌（EAEC）的基因组特征。该分离株属于序列类型（ST）38，是已知的具有多重耐药性（MDR）的肠道聚集性大肠埃希菌（EAEC）/致病性大肠埃希菌（UPEC）杂交菌株。该菌株携带编码对碳青霉烯类、第三代头孢菌素、多粘菌素、氟喹诺酮类、氨基糖苷类、磷霉素、硝基呋喃妥因、磺胺类药物的多重耐药性的基因和多种外排泵基因。这些抗药性在共生菌和病原体中的种间水平转移、菌株间和克隆传播将令人担忧。我们对此类 PDR 菌株的传播感到担忧。这些菌株的基因组特征将有助于了解 EAEC/UPEC 杂交菌株的基因组成，并开发新的疫苗/诊断和治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Indian Journal of Medical Microbiology IMMUNOLOGY-

CiteScore

2.20

自引率

0.00%

发文量

154

审稿时长

73 days

期刊介绍： Manuscripts of high standard in the form of original research, multicentric studies, meta analysis, are accepted. Current reports can be submitted as brief communications. Case reports must include review of current literature, clinical details, outcome and follow up. Letters to the editor must be a comment on or pertain to a manuscript already published in the IJMM or in relation to preliminary communication of a larger study. Review articles, Special Articles or Guest Editorials are accepted on invitation.