Reduced cerebrospinal fluid motion in patients with Parkinson's disease revealed by magnetic resonance imaging with low b-value diffusion weighted imaging.

IF 5.9 1区医学 Q1 NEUROSCIENCES

Fluids and Barriers of the CNS Pub Date : 2024-05-09 DOI:10.1186/s12987-024-00542-8

Gabriela Pierobon Mays, Kilian Hett, Jarrod Eisma, Colin D McKnight, Jason Elenberger, Alexander K Song, Ciaran Considine, Wesley T Richerson, Caleb Han, Adam Stark, Daniel O Claassen, Manus J Donahue

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引用次数: 0

Abstract

Background: Parkinson's disease is characterized by dopamine-responsive symptoms as well as aggregation of α-synuclein protofibrils. New diagnostic methods assess α-synuclein aggregation characteristics from cerebrospinal fluid (CSF) and recent pathophysiologic mechanisms suggest that CSF circulation disruptions may precipitate α-synuclein retention. Here, diffusion-weighted MRI with low-to-intermediate diffusion-weightings was applied to test the hypothesis that CSF motion is reduced in Parkinson's disease relative to healthy participants.

Methods: Multi-shell diffusion weighted MRI (spatial resolution = 1.8 × 1.8 × 4.0 mm) with low-to-intermediate diffusion weightings (b-values = 0, 50, 100, 200, 300, 700, and 1000 s/mm²) was applied over the approximate kinetic range of suprasellar cistern fluid motion at 3 Tesla in Parkinson's disease (n = 27; age = 66 ± 6.7 years) and non-Parkinson's control (n = 32; age = 68 ± 8.9 years) participants. Wilcoxon rank-sum tests were applied to test the primary hypothesis that the noise floor-corrected decay rate of CSF signal as a function of b-value, which reflects increasing fluid motion, is reduced within the suprasellar cistern of persons with versus without Parkinson's disease and inversely relates to choroid plexus activity assessed from perfusion-weighted MRI (significance-criteria: p < 0.05).

Results: Consistent with the primary hypothesis, CSF decay rates were higher in healthy (D = 0.00673 ± 0.00213 mm²/s) relative to Parkinson's disease (D = 0.00517 ± 0.00110 mm²/s) participants. This finding was preserved after controlling for age and sex and was observed in the posterior region of the suprasellar cistern (p < 0.001). An inverse correlation between choroid plexus perfusion and decay rate in the voxels within the suprasellar cistern (Spearman's-r=-0.312; p = 0.019) was observed.

Conclusions: Multi-shell diffusion MRI was applied to identify reduced CSF motion at the level of the suprasellar cistern in adults with versus without Parkinson's disease; the strengths and limitations of this methodology are discussed in the context of the growing literature on CSF flow.

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低 b 值弥散加权成像磁共振成像显示帕金森病患者脑脊液运动减少。

背景：帕金森病的特征是多巴胺反应症状以及α-突触核蛋白原纤维的聚集。新的诊断方法可评估脑脊液（CSF）中α-突触核蛋白的聚集特征，而最新的病理生理机制表明，脑脊液循环障碍可能会导致α-突触核蛋白潴留。在此，我们采用中低度弥散加权核磁共振成像来检验帕金森病患者脑脊液运动相对于健康患者减少的假设：在帕金森病患者（n = 27；年龄 = 66 ± 6.7 岁）和非帕金森病对照组患者（n = 32；年龄 = 68 ± 8.9 岁）的近似鞘上贮液流运动范围内，在 3 特斯拉条件下应用多壳弥散加权 MRI（空间分辨率 = 1.8 × 1.8 × 4.0 mm）和中低弥散加权（b 值 = 0、50、100、200、300、700 和 1000 s/mm2）。应用 Wilcoxon 秩和检验来检验主要假设，即 CSF 信号的噪声底限校正衰减率与 b 值的函数关系（b 值反映了流体运动的增加）在帕金森病患者和非帕金森病患者的蝶鞍上贮水池内均有所降低，并且与灌注加权 MRI 评估的脉络丛活动成反比（显著性标准：p 结果：与主要假设一致，CSF 信号的噪声底限校正衰减率与 b 值的函数关系（b 值反映了流体运动的增加）在帕金森病患者和非帕金森病患者的蝶鞍上贮水池内均有所降低，并且与灌注加权 MRI 评估的脉络丛活动成反比：与主要假设一致，健康人（D = 0.00673 ± 0.00213 mm2/s）的 CSF 衰减率高于帕金森病患者（D = 0.00517 ± 0.00110 mm2/s）。在控制了年龄和性别后，这一结果仍保持不变，并在蝶窦上的后部区域观察到（P 结论）：多壳弥散核磁共振成像可用于识别帕金森病成人患者与非帕金森病患者在蝶鞍上水平的脑脊液运动减弱情况；该方法的优势和局限性将在脑脊液流动文献不断增加的背景下进行讨论。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Fluids and Barriers of the CNS Neuroscience-Developmental Neuroscience

CiteScore

10.70

自引率

8.20%

发文量

审稿时长

14 weeks

期刊介绍： "Fluids and Barriers of the CNS" is a scholarly open access journal that specializes in the intricate world of the central nervous system's fluids and barriers, which are pivotal for the health and well-being of the human body. This journal is a peer-reviewed platform that welcomes research manuscripts exploring the full spectrum of CNS fluids and barriers, with a particular focus on their roles in both health and disease. At the heart of this journal's interest is the cerebrospinal fluid (CSF), a vital fluid that circulates within the brain and spinal cord, playing a multifaceted role in the normal functioning of the brain and in various neurological conditions. The journal delves into the composition, circulation, and absorption of CSF, as well as its relationship with the parenchymal interstitial fluid and the neurovascular unit at the blood-brain barrier (BBB).