Niacinamide: a review on dermal delivery strategies and clinical evidence.

IF 5.7 3区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Drug Delivery and Translational Research Pub Date : 2024-12-01 Epub Date: 2024-05-09 DOI:10.1007/s13346-024-01593-y
Rong Rong Ong, Choon Fu Goh
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Abstract

Niacinamide, an active form of vitamin B3, is recognised for its significant dermal benefits including skin brightening, anti-ageing properties and the protection of the skin barrier. Its widespread incorporation into cosmetic products, ranging from cleansers to serums, is attributed to its safety profile and proven efficacy. Recently, topical niacinamide has also been explored for other pharmaceutical applications, including skin cancers. Therefore, a fundamental understanding of the skin permeation behaviour of niacinamide becomes crucial for formulation design. Given the paucity of a comprehensive review on this aspect, we provide insights into the mechanisms of action of topically applied niacinamide and share the current strategies used to enhance its skin permeation. This review also consolidates clinical evidence of topical niacinamide for its cosmeceutical uses and as treatment for some skin disorders, including dermatitis, acne vulgaris and actinic keratosis. We also emphasise the current exploration and perspectives on the delivery designs of topical niacinamide, highlighting the potential development of formulations focused on enhancing skin permeation, particularly for clinical benefits.

Abstract Image

烟酰胺:皮肤给药策略和临床证据综述。
烟酰胺是维生素 B3 的一种活性形式,具有显著的皮肤功效,包括美白、抗衰老和保护皮肤屏障。烟酰胺被广泛应用于从洁面乳到精华液等各种化妆品中,其安全性和功效已得到证实。最近,人们还在探索烟酰胺的其他医药应用,包括皮肤癌。因此,从根本上了解烟酰胺的皮肤渗透行为对配方设计至关重要。鉴于这方面的综合综述很少,我们将深入探讨烟酰胺外用药的作用机制,并分享目前用于提高烟酰胺皮肤渗透性的策略。这篇综述还整合了烟酰胺外用的临床证据,包括烟酰胺的药妆用途和治疗皮炎、寻常痤疮和光化性角化病等皮肤疾病。我们还强调了目前对烟酰胺外用给药设计的探索和展望,突出强调了以增强皮肤渗透性为重点的制剂的潜在开发前景,尤其是在临床治疗方面。
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来源期刊
Drug Delivery and Translational Research
Drug Delivery and Translational Research MEDICINE, RESEARCH & EXPERIMENTALPHARMACOL-PHARMACOLOGY & PHARMACY
CiteScore
11.70
自引率
1.90%
发文量
160
期刊介绍: The journal provides a unique forum for scientific publication of high-quality research that is exclusively focused on translational aspects of drug delivery. Rationally developed, effective delivery systems can potentially affect clinical outcome in different disease conditions. Research focused on the following areas of translational drug delivery research will be considered for publication in the journal. Designing and developing novel drug delivery systems, with a focus on their application to disease conditions; Preclinical and clinical data related to drug delivery systems; Drug distribution, pharmacokinetics, clearance, with drug delivery systems as compared to traditional dosing to demonstrate beneficial outcomes Short-term and long-term biocompatibility of drug delivery systems, host response; Biomaterials with growth factors for stem-cell differentiation in regenerative medicine and tissue engineering; Image-guided drug therapy, Nanomedicine; Devices for drug delivery and drug/device combination products. In addition to original full-length papers, communications, and reviews, the journal includes editorials, reports of future meetings, research highlights, and announcements pertaining to the activities of the Controlled Release Society.
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