Association Between Statin Use and the Incidence of Clinically Diagnosed Osteoarthritis: A Nationwide Retrospective Cohort Study in Taiwan.

IF 2.7 4区医学 Q1 ORTHOPEDICS

CARTILAGE Pub Date : 2024-05-10 DOI:10.1177/19476035241247700

Guan-Ling Lin, Joseph Jordan Keller, Li-Hsuan Wang

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引用次数: 0

Abstract

Objective: To investigate the effect of higher cumulative defined daily dose per year (cDDD/y) compared with lower cDDD/y of statin use in the incidence of any joint osteoarthritis (OA).

Design: In this population-based retrospective cohort study, patients who were aged ≥40 years were newly initiated on statin therapy between 2002 and 2011, and had a statin prescription for ≥90 days in the first year of treatment were identified from the 2000 Longitudinal Generation Tracking Database. All patients were separated into groups with higher cDDD/y (>120 cDDD/y) and lower cDDD/y (≤120 cDDD/y; as an active comparator) values. Propensity score matching was performed to balance potential confounders. All recruited patients were followed up for 8 years. Marginal Cox proportional hazard models were used to estimate time-to-event outcomes of OA.

Results: Compared with lower cDDD/y use, higher cDDD/y use did not reduce the risk of any joint OA (adjusted hazard ratio, 1.07; 95% confidence interval, 0.99-1.14). Dose-related analysis did not reveal any dose-dependent association. A series of sensitivity analyses showed similar results. Joint-specific analyses revealed that statin did not reduce the incidence of knee, hand, hip, and weight-bearing (knee or hip) OA.

Conclusions: Higher cDDD/y statin use did not reduce the risk of OA in this Taiwanese nationwide cohort study. The complexity of OA pathogenesis might contribute to the ineffectiveness of statin. Repurposing statin with its anti-inflammation properties might be ineffective for OA development, and balancing the catabolism and anabolism of cartilage might be a major strategy for OA prevention.

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他汀类药物的使用与临床诊断的骨关节炎发病率之间的关系：台湾全国性回顾性队列研究》。

目的研究使用他汀类药物时，较高的每年规定日累积剂量（cDDD/y）与较低的cDDD/y相比，对任何关节骨关节炎（OA）发病率的影响：在这项基于人群的回顾性队列研究中，研究人员从2000年纵向世代追踪数据库中筛选出2002年至2011年间新开始他汀类药物治疗、年龄≥40岁、治疗第一年他汀类药物处方时间≥90天的患者。所有患者被分为 cDDD/y 值较高组（>120 cDDD/y）和 cDDD/y 值较低组（≤120 cDDD/y；作为活性比较组）。为平衡潜在的混杂因素，进行了倾向评分匹配。对所有招募的患者进行了为期 8 年的随访。采用边际 Cox 比例危险模型估算 OA 的时间到事件结果：结果：与较低的cDDD/年使用率相比，较高的cDDD/年使用率并未降低任何关节OA的风险（调整后危险比为1.07；95%置信区间为0.99-1.14）。剂量相关分析未发现任何剂量依赖关系。一系列敏感性分析显示了类似的结果。关节特异性分析显示，他汀类药物并未降低膝关节、手部、髋关节和负重（膝关节或髋关节）OA的发病率：结论：在这项台湾全国性队列研究中，使用他汀类药物的cDDD/y越高，患OA的风险就越低。OA发病机制的复杂性可能是他汀无效的原因之一。他汀类药物的抗炎特性可能对 OA 的发展无效，而平衡软骨的分解代谢和合成代谢可能是预防 OA 的主要策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

CARTILAGE ORTHOPEDICS-

CiteScore

6.90

自引率

7.10%

发文量

期刊介绍： CARTILAGE publishes articles related to the musculoskeletal system with particular attention to cartilage repair, development, function, degeneration, transplantation, and rehabilitation. The journal is a forum for the exchange of ideas for the many types of researchers and clinicians involved in cartilage biology and repair. A primary objective of CARTILAGE is to foster the cross-fertilization of the findings between clinical and basic sciences throughout the various disciplines involved in cartilage repair. The journal publishes full length original manuscripts on all types of cartilage including articular, nasal, auricular, tracheal/bronchial, and intervertebral disc fibrocartilage. Manuscripts on clinical and laboratory research are welcome. Review articles, editorials, and letters are also encouraged. The ICRS envisages CARTILAGE as a forum for the exchange of knowledge among clinicians, scientists, patients, and researchers. The International Cartilage Repair Society (ICRS) is dedicated to promotion, encouragement, and distribution of fundamental and applied research of cartilage in order to permit a better knowledge of function and dysfunction of articular cartilage and its repair.