Custom protein nanoparticles for targeted drug delivery

IF 12.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nature Structural & Molecular Biology Pub Date : 2024-05-09 DOI:10.1038/s41594-024-01289-4

引用次数: 0

Abstract

Targeted biologics delivery requires programming multicomponent protein nanomaterials to enable selective targeting and response to environment changes in a single unified framework. A novel protein nanoparticle platform has been designed to modulate cell-surface target specificity, cargo packaging, and pH-dependent release of encapsulated cargo, providing exciting possibilities in biologics delivery.

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用于靶向给药的定制蛋白质纳米颗粒

靶向生物制剂递送需要对多组分蛋白质纳米材料进行编程，以便在一个统一的框架内实现选择性靶向并对环境变化做出反应。我们设计了一种新型蛋白质纳米粒子平台，用于调节细胞表面靶标特异性、货物包装以及随 pH 值变化的封装货物释放，为生物制剂递送提供了令人兴奋的可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Structural & Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-BIOPHYSICS

CiteScore

22.00

自引率

1.80%

发文量

160

审稿时长

3-8 weeks

期刊介绍： Nature Structural & Molecular Biology is a comprehensive platform that combines structural and molecular research. Our journal focuses on exploring the functional and mechanistic aspects of biological processes, emphasizing how molecular components collaborate to achieve a particular function. While structural data can shed light on these insights, our publication does not require them as a prerequisite.