Minimally Invasive Semiconductor Laser Surgery Combined with 5-ALA Photodynamic Therapy for a Chronic Hyperplastic Candidiasis Patient Who Is Ineffective to Antifungal Therapy.

IF 1.8 Q2 SURGERY
Feng Wang, Gang Zhou, Jing Zhang
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引用次数: 0

Abstract

Background: Chronic hyperplastic candidiasis (CHC) is a chronic oral mucosal infection caused by Candida, which has potential for malignant transformation. Diagnosing CHC can be challenging due to its various manifestations. In addition, fungal treatments often prove to be ineffective, highlighting the urgent need for a new safe and efficient treatment approach. Given the potential of CHC to transform into malignancy, it is crucial to emphasize dynamic monitoring and follow-up after treatment. Objective: We attempted to investigate the effect of semiconductor laser pretreatment combined with 5-amino-levulinic acid (5-ALA) photodynamic therapy (PDT) for CHC. Methods: We presented the successful treatment of CHC with mild dysplasia in a 30-year-old man using semiconductor laser and 5-ALA PDT after antifungal therapy proved ineffective. Toluidine blue staining, autofluorescence imaging, and DNA image cytometry were combined to dynamically monitor the progress of the disease. Results: We have obtained positive outcomes with the use of laser combined with PDT treatment. The patients experienced only mild adverse reactions after the treatment, and there was no indication of recurrence or malignant transformation during the subsequent follow-up period, as observed through various auxiliary examinations. Conclusions: This case report suggests that semiconductor laser surgery combined with PDT could be a promising treatment option for patients with CHC who do not respond to antifungal therapy. In addition, the use of combined noninvasive examinations might provide a more accurate assessment of malignant transformation in patients with CHC.

微创半导体激光手术结合 5-ALA 光动力疗法治疗对抗真菌疗法无效的慢性增生性念珠菌病患者。
背景:慢性增生性念珠菌病(CHC)是由念珠菌引起的慢性口腔黏膜感染,有恶变的可能。由于慢性增生性念珠菌病的表现多种多样,因此诊断该病非常困难。此外,真菌治疗往往无效,因此迫切需要一种新的安全高效的治疗方法。鉴于 CHC 有可能转化为恶性肿瘤,因此强调治疗后的动态监测和随访至关重要。研究目的我们尝试研究半导体激光预处理联合 5- 氨基乙酰丙酸(5-ALA)光动力疗法(PDT)治疗 CHC 的效果。方法:我们介绍了在抗真菌治疗无效后,使用半导体激光和 5-ALA 光动力疗法成功治疗一名 30 岁男性轻度发育不良的 CHC 的病例。结合甲苯胺蓝染色、自发荧光成像和 DNA 图像细胞仪来动态监测疾病的进展。结果:我们使用激光联合光导疗法取得了良好的疗效。患者在治疗后仅出现轻微不良反应,在随后的随访期间,通过各种辅助检查也未发现复发或恶变迹象。结论:本病例报告表明,对于抗真菌治疗无效的 CHC 患者,半导体激光手术联合光动力疗法是一种很有前景的治疗方案。此外,联合使用非侵入性检查可更准确地评估 CHC 患者的恶性转化情况。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.10
自引率
0.00%
发文量
0
期刊介绍: Photobiomodulation, Photomedicine, and Laser Surgery Editor-in-Chief: Michael R Hamblin, PhD Co-Editor-in-Chief: Heidi Abrahamse, PhD
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