History of periodontitis as a risk factor for implant failure and incidence of peri-implantitis: A systematic review, meta-analysis, and trial sequential analysis of prospective cohort studies

IF 3.7 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Implant Dentistry and Related Research Pub Date : 2024-05-08 DOI:10.1111/cid.13330

Matteo Serroni, Wenche S. Borgnakke, Luigi Romano, Giuseppe Balice, Michele Paolantonio, Muhammad H. A. Saleh, Andrea Ravidà

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Abstract

Introduction

Dental implants are widely employed as dependable replacements for lost teeth. However, it is crucial to establish, solely through prospective cohort studies, whether a history of periodontitis indeed constitutes a significant risk factor for implant failure.

Methods

A systematic literature search was conducted in October 2022 in several electronic databases with subsequent manual updates. Only original prospective cohort studies evaluating the implant (loss) rate ≥1 year after implant loading were included. Logarithmic risk ratio and weighted mean differences were calculated. Study results were summarized using random effects meta-analyses evaluated by trial sequential analyses. The Newcastle-Ottawa scale evaluated study bias and the GRADE approach assessed the certainty/quality of the evidence.

Results

A total of 14 publications reporting on 12 prospective cohort studies were included. Low evidence certainty/quality evidence due to the absence of randomized clinical trials revealed significantly greater odds of failure in patients with a history of periodontitis at follow-ups both after ≤5 years (RR = 1.62; 95% CI: 1.71–2.37; p = 0.013) and >5 years (RR = 2.26; 95% CI: 1.12–4.53; p = 0.023). The incidence of peri-implantitis (RR = 4.09; 95% CI: 1.93–8.58; p < 0.001) and the weighted mean (WM) of marginal bone loss (WM difference = 0.75 mm; 95% CI: 0.18–1.31; p < 0.05) were statistically significantly greater in the periodontally compromised group, whereas there was no significant difference between the two groups for peri-implant probing depth.

Conclusion

A history of periodontitis can be considered a significant risk factor for incident implant failure, peri-implantitis, and greater marginal bone loss.

Abstract Image

查看原文本刊更多论文

牙周炎病史是种植失败和种植体周围炎发病率的风险因素：前瞻性队列研究的系统回顾、荟萃分析和试验序列分析。

简介种植牙作为失牙的可靠替代物被广泛使用。然而，仅通过前瞻性队列研究来确定牙周炎病史是否确实是导致种植失败的重要风险因素至关重要：方法：2022 年 10 月，我们在多个电子数据库中进行了系统性文献检索，并随后进行了人工更新。方法：2022 年 10 月，在多个电子数据库中进行了系统性文献检索，并进行了人工更新。仅纳入了评估种植体植入≥1 年后种植体（脱落）率的原始前瞻性队列研究。计算对数风险比和加权平均差。研究结果采用随机效应荟萃分析法进行总结，并通过试验序列分析法进行评估。纽卡斯尔-渥太华量表评估了研究偏倚，GRADE方法评估了证据的确定性/质量：结果：共纳入了 14 篇出版物，报告了 12 项前瞻性队列研究。由于缺乏随机临床试验，证据的确定性/质量较低，结果显示，有牙周炎病史的患者在随访≤5年（OR = 1.65; 95% CI: 1.12-2.44; p = 0.012）和>5年（OR = 2.36; 95% CI: 1.13-4.95; p = 0.023）后失败的几率明显更高。种植体周围炎的发生率（OR = 5.93；95% CI：2.75-12.8；P 结论：牙周炎病史可能会导致种植体周围炎：牙周炎病史可被视为种植失败、种植体周围炎和边缘骨质流失的重要风险因素。

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来源期刊

Clinical Implant Dentistry and Related Research 医学-牙科与口腔外科

CiteScore

6.00

自引率

13.90%

发文量

103

审稿时长

4-8 weeks

期刊介绍： The goal of Clinical Implant Dentistry and Related Research is to advance the scientific and technical aspects relating to dental implants and related scientific subjects. Dissemination of new and evolving information related to dental implants and the related science is the primary goal of our journal. The range of topics covered by the journals will include but be not limited to: New scientific developments relating to bone Implant surfaces and their relationship to the surrounding tissues Computer aided implant designs Computer aided prosthetic designs Immediate implant loading Immediate implant placement Materials relating to bone induction and conduction New surgical methods relating to implant placement New materials and methods relating to implant restorations Methods for determining implant stability A primary focus of the journal is publication of evidenced based articles evaluating to new dental implants, techniques and multicenter studies evaluating these treatments. In addition basic science research relating to wound healing and osseointegration will be an important focus for the journal.