TKL family kinases in human apicomplexan pathogens

IF 1.4 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular and biochemical parasitology Pub Date : 2024-05-06 DOI:10.1016/j.molbiopara.2024.111628

Dima Hajj Ali, Rajshekhar Y. Gaji

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引用次数: 0

Abstract

Apicomplexan parasites are the primary causative agents of many human diseases, including malaria, toxoplasmosis, and cryptosporidiosis. These opportunistic pathogens undergo complex life cycles with multiple developmental stages, wherein many key steps are regulated by phosphorylation mechanisms. The genomes of apicomplexan pathogens contain protein kinases from different groups including tyrosine kinase-like (TKL) family proteins. Although information on the role of TKL kinases in apicomplexans is quite limited, recent studies have revealed the important role of this family of proteins in apicomplexan biology. TKL kinases in these protozoan pathogens show unique organization with many novel domains thus making them attractive candidates for drug development. In this mini review, we summarize the current understanding of the role of TKL kinases in human apicomplexan pathogens’ (Toxoplasma gondii, Plasmodium falciparum and Cryptosporidium parvum) biology and pathogenesis.

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人类吸虫病原体中的 TKL 家族激酶

表皮复合寄生虫是许多人类疾病的主要致病原，包括疟疾、弓形虫病和隐孢子虫病。这些机会性病原体经历复杂的生命周期和多个发育阶段，其中许多关键步骤受磷酸化机制调控。apicomplexan 病原体的基因组中含有不同类群的蛋白激酶，包括酪氨酸激酶样（TKL）家族蛋白。虽然有关 TKL 激酶在类凋亡球菌中作用的信息非常有限，但最近的研究揭示了该家族蛋白在类凋亡球菌生物学中的重要作用。这些原生动物病原体中的 TKL 激酶显示出独特的组织结构，具有许多新颖的结构域，因此对药物开发具有吸引力。在这篇微型综述中，我们总结了目前对 TKL 激酶在人类类人猿病原体（弓形虫、恶性疟原虫和副隐孢子虫）生物学和致病机理中作用的理解。

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来源期刊

Molecular and biochemical parasitology 医学-寄生虫学

CiteScore

2.90

自引率

0.00%

发文量

审稿时长

63 days

期刊介绍： The journal provides a medium for rapid publication of investigations of the molecular biology and biochemistry of parasitic protozoa and helminths and their interactions with both the definitive and intermediate host. The main subject areas covered are: • the structure, biosynthesis, degradation, properties and function of DNA, RNA, proteins, lipids, carbohydrates and small molecular-weight substances • intermediary metabolism and bioenergetics • drug target characterization and the mode of action of antiparasitic drugs • molecular and biochemical aspects of membrane structure and function • host-parasite relationships that focus on the parasite, particularly as related to specific parasite molecules. • analysis of genes and genome structure, function and expression • analysis of variation in parasite populations relevant to genetic exchange, pathogenesis, drug and vaccine target characterization, and drug resistance. • parasite protein trafficking, organelle biogenesis, and cellular structure especially with reference to the roles of specific molecules • parasite programmed cell death, development, and cell division at the molecular level.