Periodontitis and systemic parameters in chronic kidney disease: Systematic review and meta-analysis.

IF 2.9 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Oral diseases Pub Date : 2024-10-01 Epub Date: 2024-05-09 DOI:10.1111/odi.14981

Suélem Maria Santana Pinheiro Ferreira, Isaac Suzart Gomes-Filho, Maria da Conceição Nascimento Costa, Simone Seixas da Cruz, Carolina Lara Neves, Carlos Alberto Lima da Silva, Kaio Vinicius Freitas de Andrade, Marcela Beatriz Aguiar Moreira, Alexandre Marcelo Hintz, Maria Isabel Pereira Vianna

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引用次数: 0

Abstract

Objective: To perform a systematic review with meta-analysis to assess recent scientific evidence on the association between periodontitis and systemic parameters/conditions in individuals with chronic kidney disease (CKD).

Materials and methods: The search for studies was performed in MedLine/PubMed, Scopus, Web of Science, and BIREME databases. Reference lists of selected articles were also searched. Studies with different epidemiological designs evaluating the influence of exposure to periodontitis on serum markers and mortality in individuals with CKD were eligible for inclusion. Three independent reviewers performed the article selection and data extraction. The assessment of methodological quality used the adapted Newcastle Ottawa Scale. Random effects meta-analysis was performed to calculate association measurements and 95% confidence intervals.

Results: In total, 3053 records were identified in the database search, with only 25 studies meeting the eligibility criteria and, of these, 10 studies contributed data for meta-analysis. Using a random-effects model, periodontitis was associated with hypoalbuminemia (PR_unadjusted = 2.47; 95%CI:1.43-4.26), with high levels of C-reactive protein (PR_unadjusted = 1.35; 95%CI%:1.12-1.64), death from cardiovascular disease (RR_unadjusted = 2.29; 95%CI:1.67-3.15) and death from all causes (RR_unadjusted = 1.73; 95%CI:1.32-2.27).

Conclusions: The findings of this review validated a positive association between periodontitis and serum markers and mortality data in individuals with CKD.

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牙周炎与慢性肾脏病的系统参数：系统回顾和荟萃分析。

摘要通过荟萃分析进行系统综述，评估慢性肾脏病（CKD）患者牙周炎与全身指标/症状之间关系的最新科学证据：在 MedLine/PubMed、Scopus、Web of Science 和 BIREME 数据库中搜索研究。同时还检索了所选文章的参考文献目录。符合纳入条件的研究均采用不同的流行病学设计，评估牙周炎暴露对慢性肾脏病患者血清标志物和死亡率的影响。三位独立审稿人对文章进行了筛选和数据提取。方法学质量评估采用改编的纽卡斯尔-渥太华量表。随机效应荟萃分析用于计算相关性测量值和95%置信区间：数据库搜索共发现 3053 条记录，只有 25 项研究符合资格标准，其中 10 项研究为元分析提供了数据。使用随机效应模型，牙周炎与低白蛋白血症（PRunadjusted = 2.47；95%CI:1.43-4.26）、高水平的C反应蛋白（PRunadjusted = 1.35；95%CI%:1.12-1.64）、心血管疾病导致的死亡（RRunadjusted = 2.29；95%CI:1.67-3.15）以及所有原因导致的死亡（RRunadjusted = 1.73；95%CI:1.32-2.27）相关：本综述的结果验证了牙周炎与血清标志物和慢性肾脏病患者的死亡率数据之间存在正相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral diseases 医学-牙科与口腔外科

CiteScore

7.60

自引率

5.30%

发文量

325

审稿时长

4-8 weeks

期刊介绍： Oral Diseases is a multidisciplinary and international journal with a focus on head and neck disorders, edited by leaders in the field, Professor Giovanni Lodi (Editor-in-Chief, Milan, Italy), Professor Stefano Petti (Deputy Editor, Rome, Italy) and Associate Professor Gulshan Sunavala-Dossabhoy (Deputy Editor, Shreveport, LA, USA). The journal is pre-eminent in oral medicine. Oral Diseases specifically strives to link often-isolated areas of dentistry and medicine through broad-based scholarship that includes well-designed and controlled clinical research, analytical epidemiology, and the translation of basic science in pre-clinical studies. The journal typically publishes articles relevant to many related medical specialties including especially dermatology, gastroenterology, hematology, immunology, infectious diseases, neuropsychiatry, oncology and otolaryngology. The essential requirement is that all submitted research is hypothesis-driven, with significant positive and negative results both welcomed. Equal publication emphasis is placed on etiology, pathogenesis, diagnosis, prevention and treatment.