Pharmacokinetics of famotidine in goats after intravenous administration

IF 1.5 4区 农林科学 Q3 PHARMACOLOGY & PHARMACY
Olivia G. Escher, Joe S. Smith, Kamryn Christopher, Bryan Hogan, Lainey E. Harvill, Makenna Hopson, Sherry Cox
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Abstract

There is currently limited pharmacokinetic data for the use of famotidine in goats for treatment and prevention of abomasal ulceration. The objective of this study was to determine the pharmacokinetic parameters after a single intravenous administration of famotidine (0.6 mg/kg). Famotidine was administered to six healthy goats and plasma samples were collected over a 24-h period. The famotidine concentration was measured using reverse phase high-performance liquid chromatography (HPLC). Non-compartmental analysis was then used to determine the pharmacokinetic parameters. The maximum plasma concentration was estimated at 5476.68 ± 1530.51 ng/mL and elimination half-life was estimated at 18.455 ± 13.26 min. The mean residence time was determined to be 19.85 ± 12.14 min with the apparent volume of distribution being estimated at 321.924 ± 221.667. The area under the curve was determined to be 54230.08 ± 24947.6 min*ng/mL. Total exposure and elimination half-life were less than what has been reported in cattle and horses. Future research evaluating the pharmacokinetics of subcutaneous administration and looking at the pharmacodynamics of famotidine in goats is needed to determine the effectiveness of famotidine on raising pH levels of the abomasum.

静脉注射法莫替丁后山羊的药代动力学。
目前,关于法莫替丁在山羊中用于治疗和预防腹腔溃疡的药代动力学数据十分有限。本研究旨在确定法莫替丁(0.6 毫克/千克)单次静脉注射后的药代动力学参数。给六只健康山羊注射法莫替丁,并在 24 小时内采集血浆样本。采用反相高效液相色谱法测定法莫替丁的浓度。然后采用非室分析法确定药代动力学参数。最大血浆浓度估计为 5476.68 ± 1530.51 纳克/毫升,消除半衰期估计为 18.455 ± 13.26 分钟。平均停留时间为 19.85 ± 12.14 分钟,表观分布容积估计为 321.924 ± 221.667。曲线下面积为 54230.08 ± 24947.6 min*ng/mL。总暴露量和消除半衰期均低于牛和马的报告值。今后需要对山羊皮下注射的药代动力学进行评估,并研究法莫替丁的药效学,以确定法莫替丁对提高腹腔 pH 值的有效性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.10
自引率
15.40%
发文量
69
审稿时长
8-16 weeks
期刊介绍: The Journal of Veterinary Pharmacology and Therapeutics (JVPT) is an international journal devoted to the publication of scientific papers in the basic and clinical aspects of veterinary pharmacology and toxicology, whether the study is in vitro, in vivo, ex vivo or in silico. The Journal is a forum for recent scientific information and developments in the discipline of veterinary pharmacology, including toxicology and therapeutics. Studies that are entirely in vitro will not be considered within the scope of JVPT unless the study has direct relevance to the use of the drug (including toxicants and feed additives) in veterinary species, or that it can be clearly demonstrated that a similar outcome would be expected in vivo. These studies should consider approved or widely used veterinary drugs and/or drugs with broad applicability to veterinary species.
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