Association of systemic chronic inflammation during pregnancy in different periods and its trajectories with preterm birth

IF 2.5 3区医学 Q3 IMMUNOLOGY

American Journal of Reproductive Immunology Pub Date : 2024-05-09 DOI:10.1111/aji.13848

Haoyue Cheng, Zhe Zhu, Peihan Chi, Xialidan Alifu, Yan Zhuang, Shuting Si, Yiwen Qiu, Haibo Zhou, Zhicheng Peng, Yunxian Yu

{"title":"Association of systemic chronic inflammation during pregnancy in different periods and its trajectories with preterm birth","authors":"Haoyue Cheng, Zhe Zhu, Peihan Chi, Xialidan Alifu, Yan Zhuang, Shuting Si, Yiwen Qiu, Haibo Zhou, Zhicheng Peng, Yunxian Yu","doi":"10.1111/aji.13848","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Problem</h3>\n \n <p>Systemic chronic inflammation (SCI) is a prevalent characteristic observed in various diseases originating from different tissues, while the association of SCI with preterm birth (PTB) remains uncertain. This study aimed to analyze the association between a nonspecific biomarker of SCI and PTB, while also exploring the trajectories of SCI in pregnant women at risk of PTB.</p>\n </section>\n \n <section>\n \n <h3> Method of study</h3>\n \n <p>The study used data from the Electronic Medical Record System (EMRS) of a hospital in Zhejiang, China and 9226 pregnant women were included. The duration of pregnancy was categorized into four distinct periods: the first, early-second, late-second, and third trimester. Latent class trajectory modeling (LCTM) was used to identify the trajectories of SCI during pregnancy.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>The elevated WBC counts in the late-second (OR = 1.14, 95% CI: 1.06–1.23) and third (OR = 1.16, 95% CI: 1.09–1.24) trimester were both positively associated with an evaluated risk of PTB. Moreover, significant dose–response relationships were observed. There were three distinct SCI trajectories found: progressing SCI (2.89%), high SCI (7.13%), and low SCI (89.98%). Pregnant women with progressive SCI had the highest risk of PTB (OR = 3.03, 95% CI: 1.47–6.25).</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>In conclusion, elevated SCI after 23 weeks was a risk factor for PTB in healthy women, even if the SCI indicator was within normal range. Pregnant women with progressive SCI during pregnancy had the highest risk of PTB.</p>\n </section>\n </div>","PeriodicalId":7665,"journal":{"name":"American Journal of Reproductive Immunology","volume":"91 5","pages":""},"PeriodicalIF":2.5000,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of Reproductive Immunology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/aji.13848","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"IMMUNOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Problem

Systemic chronic inflammation (SCI) is a prevalent characteristic observed in various diseases originating from different tissues, while the association of SCI with preterm birth (PTB) remains uncertain. This study aimed to analyze the association between a nonspecific biomarker of SCI and PTB, while also exploring the trajectories of SCI in pregnant women at risk of PTB.

Method of study

The study used data from the Electronic Medical Record System (EMRS) of a hospital in Zhejiang, China and 9226 pregnant women were included. The duration of pregnancy was categorized into four distinct periods: the first, early-second, late-second, and third trimester. Latent class trajectory modeling (LCTM) was used to identify the trajectories of SCI during pregnancy.

Results

The elevated WBC counts in the late-second (OR = 1.14, 95% CI: 1.06–1.23) and third (OR = 1.16, 95% CI: 1.09–1.24) trimester were both positively associated with an evaluated risk of PTB. Moreover, significant dose–response relationships were observed. There were three distinct SCI trajectories found: progressing SCI (2.89%), high SCI (7.13%), and low SCI (89.98%). Pregnant women with progressive SCI had the highest risk of PTB (OR = 3.03, 95% CI: 1.47–6.25).

Conclusions

In conclusion, elevated SCI after 23 weeks was a risk factor for PTB in healthy women, even if the SCI indicator was within normal range. Pregnant women with progressive SCI during pregnancy had the highest risk of PTB.

查看原文本刊更多论文

孕期不同时期的全身慢性炎症及其轨迹与早产的关系。

问题：全身慢性炎症（SCI）是源于不同组织的各种疾病的普遍特征，而SCI与早产（PTB）之间的关系仍不确定。本研究旨在分析 SCI 的非特异性生物标志物与早产儿之间的关联，同时探索有早产儿风险的孕妇的 SCI 轨迹：研究使用了浙江某医院电子病历系统（EMRS）中的数据，共纳入 9226 名孕妇。妊娠期分为四个不同时期：妊娠头三个月、妊娠早期-中期、妊娠晚期和妊娠三个月。采用潜类轨迹模型（LCTM）来确定孕期 SCI 的轨迹：结果：妊娠晚期（OR = 1.14，95% CI：1.06-1.23）和妊娠中期（OR = 1.16，95% CI：1.09-1.24）白细胞计数升高与 PTB 风险评估呈正相关。此外，还观察到明显的剂量-反应关系。发现了三种不同的 SCI 轨迹：进行性 SCI（2.89%）、高度 SCI（7.13%）和低度 SCI（89.98%）。患有进行性 SCI 的孕妇患 PTB 的风险最高（OR = 3.03，95% CI：1.47-6.25）：总之，即使 SCI 指标在正常范围内，23 周后 SCI 升高也是健康女性患先天性脑瘫的风险因素。妊娠期SCI进行性增高的孕妇罹患PTB的风险最高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

American Journal of Reproductive Immunology 医学-免疫学

CiteScore

6.20

自引率

5.60%

发文量

314

审稿时长

2 months

期刊介绍： The American Journal of Reproductive Immunology is an international journal devoted to the presentation of current information in all areas relating to Reproductive Immunology. The journal is directed toward both the basic scientist and the clinician, covering the whole process of reproduction as affected by immunological processes. The journal covers a variety of subspecialty topics, including fertility immunology, pregnancy immunology, immunogenetics, mucosal immunology, immunocontraception, endometriosis, abortion, tumor immunology of the reproductive tract, autoantibodies, infectious disease of the reproductive tract, and technical news.