Immature platelet fraction as a systemic inflammation marker in patients with chronic obstructive pulmonary disease

IF 2.2 4区医学 Q3 HEMATOLOGY

International Journal of Laboratory Hematology Pub Date : 2024-05-09 DOI:10.1111/ijlh.14299

Nasser Absieh, Fatma Arslan, Özlem Doğan, Aslıhan Gürün Kaya, Miraç Öz, Serhat Erol, Aydın Çiledağ, Akın Kaya

{"title":"Immature platelet fraction as a systemic inflammation marker in patients with chronic obstructive pulmonary disease","authors":"Nasser Absieh, Fatma Arslan, Özlem Doğan, Aslıhan Gürün Kaya, Miraç Öz, Serhat Erol, Aydın Çiledağ, Akın Kaya","doi":"10.1111/ijlh.14299","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Introduction</h3>\n \n <p>Recently, there has been an increasing interest to find a simple, low cost, widely available biomarker for outcome predictors in chronic obstructive pulmonary disease (COPD).</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Absolute immature platelet count (AIPC), the percentage of AIPC to the total platelet count (immature platelet fraction [IPF%]), symptoms, spirometry results, age-dyspne-airflow obstruction index, and C-reactive protein tests of COPD patients and control group were recorded. Neutrophil/lymphocyte, monocyte/lymphocyte, and platelet/lymphocyte ratios and Charlson comorbidity index scores were calculated.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>One hundred and thirty-four COPD patients and 30 healthy control subjects were included in the study. Eighty-nine patients were in exacerbation (AECOPD) and 45 of them were in stable COPD period. There was a difference between IPF% values and AIPC of COPD group and control group (3.45 ± 2.41 vs. 2.04 ± 1.12, <i>p</i> = 0.01; 5.87 ± 2.45 vs. 5.20 ± 3.02, <i>p</i> = 0.01). A positive correlation was observed between IPF% with white blood cell count and neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, monocyte/lymphocyte ratio in all patients (<i>r</i> = 0.352, <i>p</i> < 0.001; <i>r</i> = 0.399, <i>p</i> < 0.001; <i>r</i> = 0.186, <i>p</i> = 0.032; <i>r</i> = 0.200, <i>p</i> = 0.021) and AECOPD (<i>r</i> = 0.356, <i>p</i> < 0.001; <i>r</i> = 0.414, <i>p</i> < 0.001; <i>r</i> = 0.239, <i>p</i> = 0.025; <i>r</i> = 0.273, <i>p</i> = 0.010). At a cut-off of 3.4, IPF% showed the highest accuracy in identifying COPD (sensitivity: 80.3%, specificity: 82.5%) using receiver-operating characteristic analysis.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>This is the first study to examine the relationship between AIPC, IPF%, and COPD. The higher IPF% values in COPD and the positive correlation between IPF% and other inflammatory markers are suggested that IPF may be an indicator of systemic inflammation in COPD.</p>\n </section>\n </div>","PeriodicalId":14120,"journal":{"name":"International Journal of Laboratory Hematology","volume":"46 5","pages":"822-829"},"PeriodicalIF":2.2000,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Laboratory Hematology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/ijlh.14299","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"HEMATOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction

Recently, there has been an increasing interest to find a simple, low cost, widely available biomarker for outcome predictors in chronic obstructive pulmonary disease (COPD).

Methods

Absolute immature platelet count (AIPC), the percentage of AIPC to the total platelet count (immature platelet fraction [IPF%]), symptoms, spirometry results, age-dyspne-airflow obstruction index, and C-reactive protein tests of COPD patients and control group were recorded. Neutrophil/lymphocyte, monocyte/lymphocyte, and platelet/lymphocyte ratios and Charlson comorbidity index scores were calculated.

Results

One hundred and thirty-four COPD patients and 30 healthy control subjects were included in the study. Eighty-nine patients were in exacerbation (AECOPD) and 45 of them were in stable COPD period. There was a difference between IPF% values and AIPC of COPD group and control group (3.45 ± 2.41 vs. 2.04 ± 1.12, p = 0.01; 5.87 ± 2.45 vs. 5.20 ± 3.02, p = 0.01). A positive correlation was observed between IPF% with white blood cell count and neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, monocyte/lymphocyte ratio in all patients (r = 0.352, p < 0.001; r = 0.399, p < 0.001; r = 0.186, p = 0.032; r = 0.200, p = 0.021) and AECOPD (r = 0.356, p < 0.001; r = 0.414, p < 0.001; r = 0.239, p = 0.025; r = 0.273, p = 0.010). At a cut-off of 3.4, IPF% showed the highest accuracy in identifying COPD (sensitivity: 80.3%, specificity: 82.5%) using receiver-operating characteristic analysis.

Conclusion

This is the first study to examine the relationship between AIPC, IPF%, and COPD. The higher IPF% values in COPD and the positive correlation between IPF% and other inflammatory markers are suggested that IPF may be an indicator of systemic inflammation in COPD.

查看原文本刊更多论文

作为慢性阻塞性肺病患者全身炎症标志物的未成熟血小板分数。

简介：最近，人们越来越关注寻找一种简单、低成本、可广泛使用的生物标记物来预测慢性阻塞性肺病（COPD）的结果：最近，人们越来越关注寻找一种简单、低成本、可广泛使用的生物标志物来预测慢性阻塞性肺疾病（COPD）的结果：方法：记录 COPD 患者和对照组的绝对未成熟血小板计数（AIPC）、AIPC 占总血小板计数的百分比（未成熟血小板分数 [IPF%]）、症状、肺活量测定结果、年龄-肾-气流阻塞指数和 C 反应蛋白检测结果。计算中性粒细胞/淋巴细胞、单核细胞/淋巴细胞、血小板/淋巴细胞比率和 Charlson 合并症指数评分：研究共纳入 134 名慢性阻塞性肺病患者和 30 名健康对照组受试者。其中 89 名患者处于病情加重期（AECOPD），45 名患者处于 COPD 稳定期。COPD 组和对照组的 IPF% 值和 AIPC 之间存在差异（3.45 ± 2.41 vs. 2.04 ± 1.12，P = 0.01；5.87 ± 2.45 vs. 5.20 ± 3.02，P = 0.01）。在所有患者中，IPF%与白细胞计数、中性粒细胞/淋巴细胞比值、血小板/淋巴细胞比值、单核细胞/淋巴细胞比值之间均呈正相关（r = 0.352，p这是首次研究 AIPC、IPF% 和慢性阻塞性肺病之间的关系。慢性阻塞性肺病患者的 IPF% 值较高，且 IPF% 与其他炎症指标呈正相关，这表明 IPF 可能是慢性阻塞性肺病患者全身炎症的一个指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

International Journal of Laboratory Hematology 医学-血液学

CiteScore

4.50

自引率

6.70%

发文量

211

审稿时长

6-12 weeks

期刊介绍： The International Journal of Laboratory Hematology provides a forum for the communication of new developments, research topics and the practice of laboratory haematology. The journal publishes invited reviews, full length original articles, and correspondence. The International Journal of Laboratory Hematology is the official journal of the International Society for Laboratory Hematology, which addresses the following sub-disciplines: cellular analysis, flow cytometry, haemostasis and thrombosis, molecular diagnostics, haematology informatics, haemoglobinopathies, point of care testing, standards and guidelines. The journal was launched in 2006 as the successor to Clinical and Laboratory Hematology, which was first published in 1979. An active and positive editorial policy ensures that work of a high scientific standard is reported, in order to bridge the gap between practical and academic aspects of laboratory haematology.