Yu. I. Belova, E. S. Mironova, T. S. Zubareva, I. M. Kvetnoy, P. K. Yablonsky
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引用次数: 0
Abstract
One of the current challenges of biomedicine is to elucidate
the multicomponent and multilevel mechanism of integrated neuroimmunoendocrine
regulation of physiological functions. Respiratory diseases are
leading in the structure of general morbidity among the population
and remain one of the most relevant problems of modern healthcare.
Numerous risk factors can contribute to the development of such
pulmonary pathologies as pneumonia, lung cancer, asthma, chronic
obstructive pulmonary disease, acute respiratory distress syndrome,
pulmonary fibrosis and others, whose incidence tends to increase
annually. In this regard, signaling molecules, which are involved
in neuroimmunoendocrine respiratory regulation and can be considered
as both prognostic biomarkers and potential therapeutic targets,
are coming into focus of modern translational biomedicine. This
review addresses the role of one of the key actors in the neuroimmunoendocrine
regulation of homeostasis, a ubiquitous transcription factor NF-κB,
in the regulation of respiratory function in health and during the
pathogenesis of lung diseases. There is ample evidence that many
pulmonary pathologies, resulting from ongoing inflammatory processes,
are associated with NF-κB activation. A comprehensive investigation
of the mechanisms underlying NF-κB activation and its relationship
with other signaling pathways will contribute to solving the main
task of translational biomedicine, the development of innovative approaches
to prevention and personalized targeted therapies for human socially
significant pathologies, including respiratory diseases.
期刊介绍：
Journal of Evolutionary Biochemistry and Physiology publishes original experimental and theoretical and review articles related to evolution of the main forms of metabolism in connection with life origin; comparative and ontogenetic physiology and biochemistry, biochemical evolution of animal world; as well as evolution of functions; morphology, pharmacology, pathophysiology and ecological physiology. The journal welcomes manuscripts from all countries in the English or Russian language.
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