G. Z. Mikhailova, I. M. Vikhlyantsev, V. L. Lakomkin
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引用次数: 0
Abstract
The review provides a brief analysis of the current knowledge
of such a post-translational modification of titin as phosphorylation,
with a focus on changes that occur during the development of heart
diseases. Studies using animal models of heart diseases and cardiac
biopsy from patients with various pathologies reveal changes in
the level of titin phosphorylation compared to healthy controls.
The development of cardiac pathology is typically accompanied by
hyperphosphorylation of the S11878 site and hypophosphorylation
of the S12022 site in the titin PEVK region, as well as changes
in the level of site phosphorylation in the titin N2B region. The
cooperative functional effect of these changes is an increase in
the stiffness of cardiomyocytes and cardiac muscle as a whole, based
on the viscoelastic properties of titin. Changes in the latter,
in turn, result from hypo- or hyperphosphorylation of certain titin
sites. The review also addresses a number of therapeutic approaches
aimed at modifying titin phosphorylation levels as a means to manage
viscoelastic properties of the pathological myocardium in order
to normalize its contractility.
期刊介绍：
Journal of Evolutionary Biochemistry and Physiology publishes original experimental and theoretical and review articles related to evolution of the main forms of metabolism in connection with life origin; comparative and ontogenetic physiology and biochemistry, biochemical evolution of animal world; as well as evolution of functions; morphology, pharmacology, pathophysiology and ecological physiology. The journal welcomes manuscripts from all countries in the English or Russian language.
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