A. A. Evtushenko, I. V. Orlov, I. P. Voronova, T. V. Kozyreva
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引用次数: 0
Abstract
Aquaporin-4 (AQP4) is the main water channel in the central
nervous system. AQP4 is highly expressed in brain structures, suggesting
its crucial role in water transport in norm and in pathology. Here,
we studied the effect of a change in the drinking regimen (water
deprivation, hyperhydration) and inherited arterial hypertension
on the expression of the AQP4 water channel gene in the hypothalamus,
a regulatory brain center of visceral functions. The expression
level of the Aqp4 gene in hyperhydrated animals
was found to be more than 1.5 times lower than in water-deprived
animals, which may reflect the need to prevent cytotoxic edema during
increased fluid intake. Rats with inherited stress-induced arterial
hypertension are characterized by an increased level of the Aqp4 gene in the hypothalamus, suggesting
the involvement of this channel in processes associated with the
regulation of brain water balance and the prevention of vasogenic
cerebral edema in arterial hypertension. Thus, the presence of the
AQP4 water channel in the brain, associated with the protection
of brain cells, is functionally determined by the state of the body,
as evidenced by bidirectional changes in Aqp4 expression
during hyperhydration and arterial hypertension.
期刊介绍：
Journal of Evolutionary Biochemistry and Physiology publishes original experimental and theoretical and review articles related to evolution of the main forms of metabolism in connection with life origin; comparative and ontogenetic physiology and biochemistry, biochemical evolution of animal world; as well as evolution of functions; morphology, pharmacology, pathophysiology and ecological physiology. The journal welcomes manuscripts from all countries in the English or Russian language.
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