P. A. Anfimova, V. V. Porseva, L. G. Pankrasheva, E. S. Shirina, P. M. Masliukov
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引用次数: 0
Abstract
The hypothalamus is a regulatory center that controls homeostasis,
reproduction, circadian rhythms, and the endocrine system. It is
also involved in the regulation of aging. The expression of insulin receptors
(INR) and insulin receptor substrate 1 (IRS1) was studied in neurons
of the arcuate (ARN), dorsomedial (DMN), and ventromedial (VMN)
tuberal nuclei of the rat hypothalamus in young (2 months), adult
(12 months), and old (24 months) male Wistar rats using immunofluorescence
staining and Western blotting. The results showed that INR and IRS1
expression in neurons of the mediobasal hypothalamic nuclei changes
in opposite directions with age. INR expression decreases in the
ARN and increases in the DMN and VMN, while IRS1 expression is unchanged
in the ARN and VMN and decreases in the DMN.
期刊介绍：
Journal of Evolutionary Biochemistry and Physiology publishes original experimental and theoretical and review articles related to evolution of the main forms of metabolism in connection with life origin; comparative and ontogenetic physiology and biochemistry, biochemical evolution of animal world; as well as evolution of functions; morphology, pharmacology, pathophysiology and ecological physiology. The journal welcomes manuscripts from all countries in the English or Russian language.
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