Morphology of Doxorubicin-Induced Organopathies under Different Intravenous Nicotinamide Riboside Administration Modes

IF 0.6 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Evolutionary Biochemistry and Physiology Pub Date : 2024-04-26 DOI:10.1134/s0022093024020108

E. Yu. Podyacheva, N. Yu. Semenova, Z. E. Artyukhina, V. A. Zinserling, Ya. G. Toropova

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Abstract

Doxorubicin (DOX) is a potent chemotherapeutic drug, but its clinical use is hindered by significant side effects, it exerts on such vital organs as the heart, kidneys, lungs, liver, and intestines. Currently, there is a lack of effective drugs that can provide simultaneous protection of the heart and other vital organs during chemotherapy. Nicotinamide riboside (NR) holds promise as a pharmacological agent, able to ensure comprehensive protection against DOX systemic toxicity. This study was aimed to evaluate morphological characteristics of the vital organs (heart, lungs, liver, kidneys) in male SPF Wistar rats (n = 60, 283 ± 22 g) with chronic doxorubicin-induced cardiomyopathy under various intravenous NR administration modes (1800 mg/kg) as a protective agent. The rats were divided into four groups: (1) intact, (2) control (DOX), (3) combined administration mode (NR+DOX), (4) preventive administration mode (NR/NR+DOX). Post-administration follow-up period spanned two months and ended with tissue sampling with subsequent morphological analysis. The development of DOX-induced cardiotoxicity was monitored by echocardiography. DOX elicited more severe morphological alterations in the heart, kidneys, and lungs compared to the liver. Both NR administration modes demonstrated protective effects, with the preventive mode showing the greatest efficacy in safeguarding the vital organs.

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不同烟酰胺核苷静脉给药模式下多柔比星诱发器官病变的形态学特征

摘要多柔比星（Doxorubicin，DOX）是一种强效化疗药物，但其对心脏、肾脏、肺脏、肝脏和肠道等重要器官产生的显著副作用阻碍了其临床应用。烟酰胺核苷（NR）有望成为一种药理制剂，能够确保对 DOX 全身毒性的全面保护。本研究旨在评估雄性 SPF Wistarrats（n = 60，283 ± 22 g）多柔比星诱导的慢性心肌病患者在不同 NR 静脉给药模式（1800 mg/kg）下作为保护剂的重要器官（心脏、肺、肝脏、肾脏）的形态特征。患者分为四组：(1) 完整组；(2) 对照组（DOX）；(3) 联合给药组（NR+DOX）；(4) 预防给药组（NR/NR+DOX）。通过超声心动图监测 DOX 诱导的心脏毒性的发展情况。与肝脏相比，DOX 在心脏、肾脏和肺部引起了更严重的形态学改变。两种 NR 给药模式均显示出保护作用，其中预防性给药模式在保护重要器官方面效果最佳。

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来源期刊

Journal of Evolutionary Biochemistry and Physiology 生物-进化生物学

自引率

33.30%

发文量

110

审稿时长

6-12 weeks

期刊介绍： Journal of Evolutionary Biochemistry and Physiology publishes original experimental and theoretical and review articles related to evolution of the main forms of metabolism in connection with life origin; comparative and ontogenetic physiology and biochemistry, biochemical evolution of animal world; as well as evolution of functions; morphology, pharmacology, pathophysiology and ecological physiology. The journal welcomes manuscripts from all countries in the English or Russian language.