Supersensitive Registration of Polyfunctional Magnetic Nanomaterials for the Rapid Detection of Molecular Markers of Diseases

Abstract

Magnetic particles based on superparamagnetic iron oxide nanocrystals find increasing application in the development of modern techniques for high-precision express determination of biomolecule concentrations. In this work, based on an original technique for the ultrasensitive detection of nonlinear magnetic nanomaterials, we develop a universal method for the use of magnetic particles as polyfunctional agents that simultaneously perform several different functions in a single assay for topical tasks of biochemical and medical diagnostics. The method is tested for the rapid quantitative detection of cardiac markers and SARS-CoV-2-associated molecular markers in complex matrices. The proposed method is promising for creating test systems for prehospital monitoring, in particular, emergency molecular diagnostics in patients with a suspected acute myocardial infarction, and the rapid detection of the coronavirus infection.