A. K. Martusevich, A. V. Surovegina, V. V. Nazarov, A. S. Fedotova
{"title":"Structural and Functional Assessment of the Condition of the Wound Bed by Microwave Dielectrometry and Laser Doppler Flowmetry","authors":"A. K. Martusevich, A. V. Surovegina, V. V. Nazarov, A. S. Fedotova","doi":"10.1134/s0006350923050160","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>The aim of the work was to develop and test a combined method to assess the structural and functional features of a burn wound and periwound area with the use of microwave dielectrometry and Doppler flowmetry. The study included 20 Wistar rats used to model a contact thermal injury and 10 intact rats. The wound condition was assessed 24 and 72 hours after burn injury. The dielectric properties of tissues were studied using a hardware and software complex for microwave (MW) resonant near-field probing. A sharp coordinated decrease in microcirculation intensity and dielectric permittivity was observed in wound tissues in the early post-injury period (day 1 after injury). The parameters gradually and partially restored by the end of day 3 after burning. A compensatory increase in microcirculatory blood flow was detected in the periwound area, leading to a higher degree of tissue hydration and, consequently, higher values of the two parameters. A regulatory imbalance of factors that ensure the capillary blood flow in the wound area and surrounding tissues was found to develop after a thermal injury. The imbalance was compensatory in nature and contributed to the inhibition of regeneration processes in the absence of adequate correction. Thus, a combination of the two methods used in the study may potentially provide more specific information in order to describe the structural and functional features of a tissue of interest and their dynamics, as was demonstrated with the example of an experimental burn wound.</p>","PeriodicalId":493,"journal":{"name":"Biophysics","volume":null,"pages":null},"PeriodicalIF":4.0330,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biophysics","FirstCategoryId":"4","ListUrlMain":"https://doi.org/10.1134/s0006350923050160","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
引用次数: 0
Abstract
The aim of the work was to develop and test a combined method to assess the structural and functional features of a burn wound and periwound area with the use of microwave dielectrometry and Doppler flowmetry. The study included 20 Wistar rats used to model a contact thermal injury and 10 intact rats. The wound condition was assessed 24 and 72 hours after burn injury. The dielectric properties of tissues were studied using a hardware and software complex for microwave (MW) resonant near-field probing. A sharp coordinated decrease in microcirculation intensity and dielectric permittivity was observed in wound tissues in the early post-injury period (day 1 after injury). The parameters gradually and partially restored by the end of day 3 after burning. A compensatory increase in microcirculatory blood flow was detected in the periwound area, leading to a higher degree of tissue hydration and, consequently, higher values of the two parameters. A regulatory imbalance of factors that ensure the capillary blood flow in the wound area and surrounding tissues was found to develop after a thermal injury. The imbalance was compensatory in nature and contributed to the inhibition of regeneration processes in the absence of adequate correction. Thus, a combination of the two methods used in the study may potentially provide more specific information in order to describe the structural and functional features of a tissue of interest and their dynamics, as was demonstrated with the example of an experimental burn wound.
BiophysicsBiochemistry, Genetics and Molecular Biology-Biophysics
CiteScore
1.20
自引率
0.00%
发文量
67
期刊介绍：
Biophysics is a multidisciplinary international peer reviewed journal that covers a wide scope of problems related to the main physical mechanisms of processes taking place at different organization levels in biosystems. It includes structure and dynamics of macromolecules, cells and tissues; the influence of environment; energy transformation and transfer; thermodynamics; biological motility; population dynamics and cell differentiation modeling; biomechanics and tissue rheology; nonlinear phenomena, mathematical and cybernetics modeling of complex systems; and computational biology. The journal publishes short communications devoted and review articles.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
