{"title":"Expression and clinicopathological significance of extracellular matrix remodeling markers in esophageal squamous carcinoma","authors":"Zhiqin Fan, Fei Chen, Yingmin Liu, Xiaotong Huang, Siyue Tian, Yuqing Ma","doi":"10.1615/critreveukaryotgeneexpr.2024053646","DOIUrl":null,"url":null,"abstract":"Esophageal squamous cell carcinoma (ESCC) is a common malignancy of the gastrointestinal tract with a single therapeutic option and a lack of effective clinical therapeutic biomarkers.Extracellular matrix (ECM) remodelling plays a pro-carcinogenic role in a variety of malignancies, but its role in esophageal squamous carcinoma remains to be elucidated.In this study, we examined the expression levels of ECM remodelling markers in 71 pairs of esophageal squamous carcinoma tissues and normal tissues adjacent to the carcinoma using immunohistochemical staining, and analysed their relationship with clinicopathological features and prognosis.The results suggested that extracellular matrix remodelling markers (Integrin αV, Fibronectin, MMP9) were abnormally highly expressed in esophageal squamous carcinoma tissues.There was a statistically significant difference between the positive expression of ECM remodelling and the TNM stage of esophageal squamous carcinoma, and there was no statistically significant correlation with age, gender and carcinoembryonic antigen expression, differentiation degree, T stage and lymph node metastasis.Overall survival rate and overall survival time were significantly lower in patients with positive ECM remodelling expression, which was an independent risk factor for poor prognosis of esophageal squamous carcinoma.","PeriodicalId":56317,"journal":{"name":"Critical Reviews in Eukaryotic Gene Expression","volume":"41 1","pages":""},"PeriodicalIF":1.5000,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Critical Reviews in Eukaryotic Gene Expression","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1615/critreveukaryotgeneexpr.2024053646","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Esophageal squamous cell carcinoma (ESCC) is a common malignancy of the gastrointestinal tract with a single therapeutic option and a lack of effective clinical therapeutic biomarkers.Extracellular matrix (ECM) remodelling plays a pro-carcinogenic role in a variety of malignancies, but its role in esophageal squamous carcinoma remains to be elucidated.In this study, we examined the expression levels of ECM remodelling markers in 71 pairs of esophageal squamous carcinoma tissues and normal tissues adjacent to the carcinoma using immunohistochemical staining, and analysed their relationship with clinicopathological features and prognosis.The results suggested that extracellular matrix remodelling markers (Integrin αV, Fibronectin, MMP9) were abnormally highly expressed in esophageal squamous carcinoma tissues.There was a statistically significant difference between the positive expression of ECM remodelling and the TNM stage of esophageal squamous carcinoma, and there was no statistically significant correlation with age, gender and carcinoembryonic antigen expression, differentiation degree, T stage and lymph node metastasis.Overall survival rate and overall survival time were significantly lower in patients with positive ECM remodelling expression, which was an independent risk factor for poor prognosis of esophageal squamous carcinoma.
期刊介绍:
Critical ReviewsTM in Eukaryotic Gene Expression presents timely concepts and experimental approaches that are contributing to rapid advances in our mechanistic understanding of gene regulation, organization, and structure within the contexts of biological control and the diagnosis/treatment of disease. The journal provides in-depth critical reviews, on well-defined topics of immediate interest, written by recognized specialists in the field. Extensive literature citations provide a comprehensive information resource.
Reviews are developed from an historical perspective and suggest directions that can be anticipated. Strengths as well as limitations of methodologies and experimental strategies are considered.