Expression and clinicopathological significance of extracellular matrix remodeling markers in esophageal squamous carcinoma

IF 1.5 4区 医学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Zhiqin Fan, Fei Chen, Yingmin Liu, Xiaotong Huang, Siyue Tian, Yuqing Ma
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引用次数: 0

Abstract

Esophageal squamous cell carcinoma (ESCC) is a common malignancy of the gastrointestinal tract with a single therapeutic option and a lack of effective clinical therapeutic biomarkers.Extracellular matrix (ECM) remodelling plays a pro-carcinogenic role in a variety of malignancies, but its role in esophageal squamous carcinoma remains to be elucidated.In this study, we examined the expression levels of ECM remodelling markers in 71 pairs of esophageal squamous carcinoma tissues and normal tissues adjacent to the carcinoma using immunohistochemical staining, and analysed their relationship with clinicopathological features and prognosis.The results suggested that extracellular matrix remodelling markers (Integrin αV, Fibronectin, MMP9) were abnormally highly expressed in esophageal squamous carcinoma tissues.There was a statistically significant difference between the positive expression of ECM remodelling and the TNM stage of esophageal squamous carcinoma, and there was no statistically significant correlation with age, gender and carcinoembryonic antigen expression, differentiation degree, T stage and lymph node metastasis.Overall survival rate and overall survival time were significantly lower in patients with positive ECM remodelling expression, which was an independent risk factor for poor prognosis of esophageal squamous carcinoma.
细胞外基质重塑标记物在食管鳞癌中的表达及其临床病理学意义
细胞外基质(ECM)重塑在多种恶性肿瘤中发挥着促癌作用,但其在食管鳞癌中的作用仍有待阐明。在这项研究中,我们采用免疫组化染色法检测了 71 对食管鳞癌组织和癌肿邻近正常组织中 ECM 重塑标记物的表达水平,并分析了它们与临床病理特征和预后的关系。结果表明,细胞外基质重塑标志物(Integrin αV、Fibronectin、MMP9)在食管鳞癌组织中异常高表达,ECM重塑标志物的阳性表达与食管鳞癌的TNM分期差异有统计学意义,与年龄、性别、癌胚抗原表达、分化程度、T分期和淋巴结转移无统计学意义。ECM重塑表达阳性的患者总生存率和总生存时间明显较低,是食管鳞癌预后不良的独立危险因素。
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来源期刊
Critical Reviews in Eukaryotic Gene Expression
Critical Reviews in Eukaryotic Gene Expression 生物-生物工程与应用微生物
CiteScore
2.70
自引率
0.00%
发文量
67
审稿时长
1 months
期刊介绍: Critical ReviewsTM in Eukaryotic Gene Expression presents timely concepts and experimental approaches that are contributing to rapid advances in our mechanistic understanding of gene regulation, organization, and structure within the contexts of biological control and the diagnosis/treatment of disease. The journal provides in-depth critical reviews, on well-defined topics of immediate interest, written by recognized specialists in the field. Extensive literature citations provide a comprehensive information resource. Reviews are developed from an historical perspective and suggest directions that can be anticipated. Strengths as well as limitations of methodologies and experimental strategies are considered.
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