Improvement of the Bioavailability of Low-Solubility Drugs by Reprecipitation on Nanostructured Surfaces

Abstract

Тhis work suggests ways to improve the bioavailability of low-solubility drugs by precipitation from solutions in universal solvents on nanostructured surfaces including nanoparticles (NPs) such as SiO₂ and Fe₃O₄. The same effect is found on metal-polymer composites containing Co, Ni, and Fe obtained from unsaturated dicarboxylates. In both cases, this is achieved by increasing the total desorption surface. The examples of resveratrol and of the preparation of the sum of furocoumarins Ammifurin show an increase of the relative desorption ratio of drugs by two orders of magnitude from the surface of nanostructured CaCO₃ particles into aqueous solutions. The results of MTT tests show the comparable effects of Ammifurin and of the used metal-polymer nanocomposites on HeLa cervical cancer cells and human HepG2 liver carcinoma, thereby making their combined use potentially possible. Thus, we propose a way to improve the bioavailability of a wide class of drugs, potentially applicable for all cases when the toxicity of the carrier NPs does not exceed the independent toxicity of the target substance. The possibility of the mutual enhancement of toxicity requires a separate study and is not considered here.