Nanocomplexes of the Anthracycline Antibiotic Daunomycin and Doxorubicin with Selenium Nanoparticles and Polyvinylpyrrolidone: Spectral and Dimensional Characteristics
{"title":"Nanocomplexes of the Anthracycline Antibiotic Daunomycin and Doxorubicin with Selenium Nanoparticles and Polyvinylpyrrolidone: Spectral and Dimensional Characteristics","authors":"A. I. Kipper, L. N. Borovikova, I. S. Garkushina","doi":"10.1134/s2635167623601560","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>The influence of the hydroxyl group in the aglycone of the antitumor antibiotic doxorubicin on the spectrophotometric and dimensional characteristics of nanocomplexes of doxorubicin–polyvinylpyrrolidone–selenium nanoparticles is established. The involvement of components of ternary complexes in intermolecular interactions is assessed using the spectrophotometric method. The radii of gyration (40–60 nm) and hydrodynamic radii (20–70 nm) of the synthesized nanocomplexes are determined using static- and dynamic-light scattering methods. The hydroxyl group present in the structure of the antitumor antibiotic contributed to the formation in an aqueous environment of a more loose, permeable shell of the nanocomplex compared to the daunomycin–polyvinylpyrrolidone–selenium nanoparticles nanocomplexes. An increase in the Se concentration during the synthesis of nanocomplexes leads to expansion of the loose shell. The revealed patterns will further contribute to the development of methods for synthesizing nanocomplexes for the modification of water-soluble antitumor antibiotics.</p>","PeriodicalId":716,"journal":{"name":"Nanotechnologies in Russia","volume":null,"pages":null},"PeriodicalIF":0.8000,"publicationDate":"2024-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nanotechnologies in Russia","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1134/s2635167623601560","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Engineering","Score":null,"Total":0}
引用次数: 0
Abstract
The influence of the hydroxyl group in the aglycone of the antitumor antibiotic doxorubicin on the spectrophotometric and dimensional characteristics of nanocomplexes of doxorubicin–polyvinylpyrrolidone–selenium nanoparticles is established. The involvement of components of ternary complexes in intermolecular interactions is assessed using the spectrophotometric method. The radii of gyration (40–60 nm) and hydrodynamic radii (20–70 nm) of the synthesized nanocomplexes are determined using static- and dynamic-light scattering methods. The hydroxyl group present in the structure of the antitumor antibiotic contributed to the formation in an aqueous environment of a more loose, permeable shell of the nanocomplex compared to the daunomycin–polyvinylpyrrolidone–selenium nanoparticles nanocomplexes. An increase in the Se concentration during the synthesis of nanocomplexes leads to expansion of the loose shell. The revealed patterns will further contribute to the development of methods for synthesizing nanocomplexes for the modification of water-soluble antitumor antibiotics.
期刊介绍：
Nanobiotechnology Reports publishes interdisciplinary research articles on fundamental aspects of the structure and properties of nanoscale objects and nanomaterials, polymeric and bioorganic molecules, and supramolecular and biohybrid complexes, as well as articles that discuss technologies for their preparation and processing, and practical implementation of products, devices, and nature-like systems based on them. The journal publishes original articles and reviews that meet the highest scientific quality standards in the following areas of science and technology studies: self-organizing structures and nanoassemblies; nanostructures, including nanotubes; functional and structural nanomaterials; polymeric, bioorganic, and hybrid nanomaterials; devices and products based on nanomaterials and nanotechnology; nanobiology and genetics, and omics technologies; nanobiomedicine and nanopharmaceutics; nanoelectronics and neuromorphic computing systems; neurocognitive systems and technologies; nanophotonics; natural science methods in a study of cultural heritage items; metrology, standardization, and monitoring in nanotechnology.
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