A pH/Redox Dual-Responsive Nanocarrier for Hypoxia-Activated Prodrug and Anticancer Prodrug in Cancer Treatment

IF 2.5 4区化学 Q3 POLYMER SCIENCE

Macromolecular Chemistry and Physics Pub Date : 2024-05-08 DOI:10.1002/macp.202470018

Jhin Chen Ho, Ching-Yi Chen

引用次数: 0

Abstract

Front Cover: A pH/redox dual-responsive and dual chemotherapeutic PNA and hypoxia-activated AQ4N prodrug micelle is developed for targeting endogenous tumor microenvironment heterogeneity. This new micelle system provides an effective strategy to increase the drug stability and reduce toxicity or side effects under physiological conditions, trigger intracellular release of potent drugs as well as enhance the therapeutic efficiency via combined chemotherapy and hypoxia-activated cancer treatment. More details can be found in article number 2300386 by Jhin Chen Ho and Ching-Yi Chen.

Abstract Image

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用于癌症治疗的低氧激活原药和抗癌原药的 pH/Redox 双响应纳米载体

封面：针对内源性肿瘤微环境异质性，开发了一种 pH/redox 双响应、双化疗 PNA 和低氧激活 AQ4N 原药胶束。这种新型胶束系统提供了一种有效的策略，可在生理条件下增加药物稳定性并降低毒性或副作用，触发强效药物的细胞内释放，以及通过联合化疗和缺氧激活癌症治疗提高治疗效率。更多详情，请参阅 Jhin Chen Ho 和 Ching-Yi Chen 的 2300386 号文章。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Macromolecular Chemistry and Physics 化学-高分子科学

CiteScore

4.30

自引率

4.00%

发文量

278

审稿时长

1.4 months

期刊介绍： Macromolecular Chemistry and Physics publishes in all areas of polymer science - from chemistry, physical chemistry, and physics of polymers to polymers in materials science. Beside an attractive mixture of high-quality Full Papers, Trends, and Highlights, the journal offers a unique article type dedicated to young scientists – Talent.