Poly (Betulinic Acid) Nanoparticles Loaded with bFGF Improve Functional Recovery After Spinal Cord Injury (Adv. Healthcare Mater. 12/2024)

IF 10 2区医学 Q1 ENGINEERING, BIOMEDICAL

Advanced Healthcare Materials Pub Date : 2024-05-07 DOI:10.1002/adhm.202470080

Xianghang Chen, Beini Wang, Yongxiu Zhou, Xuejuan Wu, Anyu Du, Abdullah Al Mamun, Yitie Xu, Shuangshuang Wang, Chang Jiang, Ling Xie, Kailiang Zhou, Siwang Hu, Jian Xiao

引用次数: 0

Abstract

Nanoparticle

In article 2303462, Kailiang Zhou, Siwang Hu, Jian Xiao and co-workers synthesize betulinic acid (BA) into polybetulinic acid (PBA) to serve as a drug carrier for bFGF and forms PBA-bFGF nanoparticles (PBA-bFGF NPs). After uptake by cells, PBA-bFGF NPs are degraded by enzymes in the cell, and the generated BA and released bFGF participate in therapy.

Abstract Image

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含 bFGF 的聚（白桦脂酸）纳米颗粒可改善脊髓损伤后的功能恢复（Adv.）

纳米颗粒在文章2303462中，周开良、胡思望、肖健及其合作者将白桦脂酸（BA）合成为聚白桦脂酸（PBA），作为bFGF的药物载体，形成PBA-bFGF纳米颗粒（PBA-bFGF NPs）。PBA-bFGF NPs 被细胞吸收后，会被细胞中的酶降解，生成的 BA 和释放的 bFGF 参与治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Healthcare Materials 工程技术-生物材料

CiteScore

14.40

自引率

3.00%

发文量

600

审稿时长

1.8 months

期刊介绍： Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.