Serum zinc concentration as a potential predictor of presarcopenia in patients with chronic liver disease: a preliminary study.

IF 3.8 Q2 GASTROENTEROLOGY & HEPATOLOGY
Translational gastroenterology and hepatology Pub Date : 2024-04-01 eCollection Date: 2024-01-01 DOI:10.21037/tgh-23-77
Mitsuyuki Suzuki, Toru Ishikawa, Kazuki Ohashi, Asami Hoshii, Hiroshi Hirosawa, Hirohito Noguchi, Terasu Honma
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Abstract

Background: Presarcopenia is a common complication of chronic liver disease. However, the relationship between serum zinc concentration and presarcopenia in patients with chronic liver disease remains unclear. Herein, we examined whether serum zinc concentration could predict presarcopenia in patients with chronic liver disease.

Methods: Between October 2015 and December 2019, 278 patients with chronic liver disease (median age, 68 years; women/men, 133/145; hepatitis B virus/hepatitis C virus/negative hepatitis B surface antigen and negative anti-hepatitis C virus antibody, 55/124/99) who underwent abdominal computed tomography (CT) and simultaneous measurement of serum zinc concentration were included. Zinc deficiency and subclinical zinc deficiency were classified using serum zinc concentration cutoff values of <60 and <80 μg/dL [based on the Japanese Society of Clinical Nutrition (JSCN) guidelines], respectively. Additionally, presarcopenia was evaluated based on the skeletal muscle mass as per the Japan Society of Hepatology (JSH)'s sarcopenia criteria.

Results: Univariate analysis revealed that the following factors were significantly associated with the presence of presarcopenia in patients with chronic liver disease: age (P<0.001), male sex (P<0.001), body mass index (BMI) (P<0.001), serum zinc concentration (P=0.005), fibrosis-4 index (P<0.001), and serum albumin concentration (P=0.03). Additionally, the median L3 skeletal muscle indices were as follows: men, non-presarcopenia group/presarcopenia group, 47.56/37.91 cm2/m2 (P<0.001); women, non-presarcopenia group/presarcopenia group, 41.64/32.88 cm2/m2 (P<0.001). Multivariate analysis using logistic regression analysis revealed that male sex [odds ratio (OR), 0.194; 95% confidence interval (CI): 0.089-0.419; P<0.001], BMI (OR, 0.666; 95% CI: 0.582-0.761; P<0.001), and serum zinc concentration <60 μg/dL (OR, 5.930; 95% CI: 1.480-23.80; P=0.01) were factors associated with presarcopenia. The OR for serum zinc concentration between 60 and 80 μg/dL was 1.910 (95% CI: 0.824-4.420; P=0.13).

Conclusions: Low serum zinc levels may be an independent predictor of presarcopenia in patients with chronic liver disease.

血清锌浓度作为慢性肝病患者肌少症前期的潜在预测指标:一项初步研究。
背景:肌肉疏松症是慢性肝病的常见并发症。然而,慢性肝病患者血清锌浓度与肝前性肌减少症之间的关系仍不清楚。在此,我们研究了血清锌浓度是否能预测慢性肝病患者的肌肉疏松症:2015年10月至2019年12月期间,纳入了278名接受腹部计算机断层扫描(CT)并同时测量血清锌浓度的慢性肝病患者(中位年龄,68岁;女性/男性,133/145;乙型肝炎病毒/丙型肝炎病毒/乙型肝炎表面抗原阴性和抗丙型肝炎病毒抗体阴性,55/124/99)。根据血清锌浓度临界值对锌缺乏症和亚临床锌缺乏症进行分类:单变量分析显示,以下因素与慢性肝病患者出现 "肌肉疏松前期 "明显相关:年龄(P2/m2)(P2/m2)(PC结论:血清锌水平低可能是慢性肝病患者出现肌肉疏松前期症状的独立预测因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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