Risk factors and circulation pattern of respiratory syncytial virus in children under 2 years in Maputo, Mozambique.

IF 2.3 4区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

International Health Pub Date : 2024-05-08 DOI:10.1093/inthealth/ihae033

Mirela Pale, Almiro Tivane, Tinne Gils, Adilson Bauhofer, Neuza Nguenha, Loira Machalele, Félix Gundane, Aunésia Marrurele, Judite Salência, Délcio Muteto, Josina Chalufo-Chilundo, Marilda Siqueira, Tufária Mussá

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引用次数: 0

Abstract

Background: Evidence on risk factors for respiratory syncytial virus (RSV) in low-resource settings is limited. In Mozambican children <2 y of age with severe acute respiratory infection (SARI), we explored risk factors for RSV, described its seasonal variation and assessed associations between RSV and a life-threatening condition.

Methods: We retrospectively included participants presenting in 2017-2018 in two hospitals in Maputo. RSV was detected and subtyped using real-time quantitative reverse transcription polymerase chain reaction on nasopharyngeal swabs. We used logistic regression and χ2 tests to assess associations and Spearman's correlation coefficient to assess the correlation between weather measurement and RSV positivity.

Results: RSV was detected in 23.1% (n=109) of 472 included children and in 50.0% (20/40) of those <3 months old. Being <3 months (vs >1 y) was associated with RSV (adjusted odds ratio 4.3 [95% confidence interval 2.1-8.5]). RSV status was not associated with experiencing a life-threatening condition. RSV A and B co-circulated during the study period, but one type predominated in each year. In 2017, the RSV positivity rate was correlated with monthly average temperature (r=0.793, p=0.002) and precipitation (r=0.596, p=0.041).

Conclusions: In Mozambican children with SARI, RSV was prevalent, especially in neonates. However, RSV was not associated with a life-threatening condition.

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莫桑比克马普托两岁以下儿童呼吸道合胞病毒的风险因素和传播模式。

背景：有关低资源环境中呼吸道合胞病毒（RSV）风险因素的证据非常有限。在莫桑比克儿童中方法：我们回顾性地纳入了 2017-2018 年在马普托两家医院就诊的患者。使用实时定量反转录聚合酶链反应对鼻咽拭子进行 RSV 检测和亚型鉴定。我们使用逻辑回归和χ2检验来评估相关性，并使用斯皮尔曼相关系数来评估天气测量与RSV阳性之间的相关性：在纳入的 472 名儿童中，23.1%（n=109）的儿童检测到 RSV，其中 50.0%（20/40）的儿童 1 岁时与 RSV 相关（调整后的几率比为 4.3 [95% 置信区间为 2.1-8.5]）。RSV 状态与危及生命的状况无关。在研究期间，RSV A 型和 B 型共同流行，但每年以一种类型为主。2017年，RSV阳性率与月平均气温（r=0.793，p=0.002）和降水量（r=0.596，p=0.041）相关：结论：在患有 SARI 的莫桑比克儿童中，RSV 很普遍，尤其是在新生儿中。然而，RSV 与危及生命的情况无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

4.50

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： International Health is an official journal of the Royal Society of Tropical Medicine and Hygiene. It publishes original, peer-reviewed articles and reviews on all aspects of global health including the social and economic aspects of communicable and non-communicable diseases, health systems research, policy and implementation, and the evaluation of disease control programmes and healthcare delivery solutions. It aims to stimulate scientific and policy debate and provide a forum for analysis and opinion sharing for individuals and organisations engaged in all areas of global health.