CAR T-cell Resistance to Oncogenic Transformation.

IF 11.5 Q1 HEMATOLOGY

Blood Cancer Discovery Pub Date : 2024-07-01 DOI:10.1158/2643-3230.BCD-23-0273

Marco Ruella, Carl H June

引用次数: 0

Abstract

In this commentary, we discuss the investigation into reports of T-cell malignancies following chimeric antigen receptor T-cell therapy. We argue that although these cases should be thoroughly examined, current data suggest that such risks with autologous chimeric antigen receptor T cells are remarkably low compared with other cancer treatments. We also emphasize the importance of continued research, transparent reporting, and participation in postauthorization safety studies.

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CAR T 细胞对致癌转化的抵抗力。

在这篇评论中，我们讨论了对 CAR T 细胞疗法后 T 细胞恶性肿瘤报告的调查。我们认为，虽然应该对这些病例进行彻底检查，但目前的数据表明，与其他癌症治疗方法相比，自体 CAR T 细胞的这种风险非常低。我们还强调了持续研究、透明报告和参与授权后安全性研究的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Blood Cancer Discovery Multiple-

CiteScore

12.70

自引率

1.80%

发文量

139

期刊介绍： The journal Blood Cancer Discovery publishes high-quality Research Articles and Briefs that focus on major advances in basic, translational, and clinical research of leukemia, lymphoma, myeloma, and associated diseases. The topics covered include molecular and cellular features of pathogenesis, therapy response and relapse, transcriptional circuits, stem cells, differentiation, microenvironment, metabolism, immunity, mutagenesis, and clonal evolution. These subjects are investigated in both animal disease models and high-dimensional clinical data landscapes. The journal also welcomes submissions on new pharmacological, biological, and living cell therapies, as well as new diagnostic tools. They are interested in prognostic, diagnostic, and pharmacodynamic biomarkers, and computational and machine learning approaches to personalized medicine. The scope of submissions ranges from preclinical proof of concept to clinical trials and real-world evidence. Blood Cancer Discovery serves as a forum for diverse ideas that shape future research directions in hematooncology. In addition to Research Articles and Briefs, the journal also publishes Reviews, Perspectives, and Commentaries on topics of broad interest in the field.