Severe Impairment of T-cell Immunity and Pulmonary GvHD Are Major Risk Factors for Nontuberculous Mycobacterial Infection After Pediatric Allogeneic Hematopoietic Stem Cell Transplantation.

IF 2.9 4区医学 Q3 IMMUNOLOGY

Pediatric Infectious Disease Journal Pub Date : 2024-09-01 Epub Date: 2024-05-07 DOI:10.1097/INF.0000000000004380

Marina Ascunce, Alejandra Coccolo, Yasmina Mozo, Fernando Baquero-Artigao, Paula Rodriguez-Molino, Carlos Toro-Rueda, Paloma García-Clemente, Elena Sánchez-Zapardiel, Eduardo López-Granados, Dolores Corral-Sánchez, David Bueno, Luisa Sisinni, Antonio Pérez-Martínez, Cristina Calvo, Teresa Del Rosal

引用次数: 0

Abstract

Hematopoietic stem cell transplant recipients are prone to infectious complications. Infections caused by nontuberculous mycobacteria have increased in adults but literature in children is scarce. We report 6 episodes of disseminated or pulmonary nontuberculous mycobacteria infection among 5 pediatric hematopoietic stem cell transplant recipients. All but one were caused by Mycobacterium avium complex. Four patients died, 2 related to nontuberculous mycobacteria infection.

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T细胞免疫力严重受损和肺部GvHD是小儿异基因造血干细胞移植后感染非结核分枝杆菌的主要风险因素。

造血干细胞移植受者容易出现感染并发症。由非结核分枝杆菌引起的感染在成人中有所增加，但儿童中的文献却很少。我们报告了5名儿童造血干细胞移植受者中发生的6例播散性或肺部非结核分枝杆菌感染。除一次外，其余均由复合分枝杆菌引起。四名患者死亡，其中两名与非结核分枝杆菌感染有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Infectious Disease Journal 医学-传染病学

CiteScore

6.30

自引率

2.80%

发文量

566

审稿时长

2-4 weeks

期刊介绍： The Pediatric Infectious Disease Journal® (PIDJ) is a complete, up-to-the-minute resource on infectious diseases in children. Through a mix of original studies, informative review articles, and unique case reports, PIDJ delivers the latest insights on combating disease in children — from state-of-the-art diagnostic techniques to the most effective drug therapies and other treatment protocols. It is a resource that can improve patient care and stimulate your personal research.