A prospective study on the histological evaluation of type 1 autoimmune pancreatitis using endoscopic ultrasound-guided fine needle biopsy with a 19-gauge Franseen needle

IF 3.2 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Journal of Hepato‐Biliary‐Pancreatic Sciences Pub Date : 2024-05-08 DOI:10.1002/jhbp.1438

Takuya Ishikawa, Kentaro Yamao, Yasuyuki Mizutani, Tadashi Iida, Kota Uetsuki, Yoshie Shimoyama, Masanao Nakamura, Kazuhiro Furukawa, Takeshi Yamamura, Hiroki Kawashima

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引用次数: 0

Abstract

Background/Purpose

To assess the diagnostic efficacy and safety of endoscopic ultrasound-guided fine needle biopsy (EUS-FNB) using a 19-gauge Franseen needle for autoimmune pancreatitis (AIP).

Methods

Twenty patients suspected of having type 1 AIP were prospectively enrolled and underwent EUS-FNB with a 19-gauge Franseen needle. Their data were compared with those of historical controls: a total of 29 type 1 AIP patients had EUS-FNB with a 22-gauge Franseen needle.

Results

Specimens suitable for histological evaluation were obtained from 19 of the 20 patients (95%), and the median total tissue area was 11.9 mm². The histological diagnosis rate of AIP was 65% (95% CI: 43.2%–82%). Adverse events were observed in three patients (15%), and a switch to 22-gauge needles occurred during transduodenal puncture in two patients. Compared to those punctured with 22-gauge needles, patients punctured with 19-gauge needles had greater prevalence of each characteristic feature of lymphoplasmacytic sclerosing pancreatitis, but the difference was not statistically significant.

Conclusions

EUS-FNB using a 19-gauge Franseen needle demonstrated favorable performance for the histological diagnosis of AIP and allowed for large tissue samples, potentially facilitating pathological diagnosis. However, during transduodenal puncture, maneuverability is reduced; therefore, the needle may need to be selected according to the puncture site.

Abstract Image

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使用 19 号弗兰森针进行内窥镜超声引导细针活检对 1 型自身免疫性胰腺炎进行组织学评估的前瞻性研究。

背景/目的：评估使用19号Franseen针进行内镜超声引导下细针活检（EUS-FNB）治疗自身免疫性胰腺炎（AIP）的诊断效果和安全性：前瞻性招募了20名疑似1型AIP患者，并使用19号Franseen针进行了EUS-FNB检查。他们的数据与历史对照组的数据进行了比较：共有 29 名 1 型 AIP 患者使用 22 号 Franseen 针进行了 EUS-FNB 检查：结果：20 位患者中有 19 位（95%）获得了适合组织学评估的标本，组织总面积中位数为 11.9 平方毫米。AIP的组织学诊断率为65%（95% CI：43.2%-82%）。三名患者（15%）出现了不良反应，两名患者在经十二指肠穿刺时改用了 22 号针头。与使用 22 号针穿刺的患者相比，使用 19 号针穿刺的患者淋巴浆细胞性硬化性胰腺炎各特征的发生率更高，但差异无统计学意义：结论：使用 19 号弗兰森针的 EUS-FNB 对 AIP 的组织学诊断有良好的表现，可获得大量组织样本，从而有助于病理诊断。然而，经十二指肠穿刺时可操作性降低，因此可能需要根据穿刺部位选择穿刺针。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Hepato‐Biliary‐Pancreatic Sciences GASTROENTEROLOGY & HEPATOLOGY-SURGERY

自引率

10.00%

发文量

178

审稿时长

6-12 weeks

期刊介绍： The Journal of Hepato-Biliary-Pancreatic Sciences (JHBPS) is the leading peer-reviewed journal in the field of hepato-biliary-pancreatic sciences. JHBPS publishes articles dealing with clinical research as well as translational research on all aspects of this field. Coverage includes Original Article, Review Article, Images of Interest, Rapid Communication and an announcement section. Letters to the Editor and comments on the journal’s policies or content are also included. JHBPS welcomes submissions from surgeons, physicians, endoscopists, radiologists, oncologists, and pathologists.