Role of urinary N-acetyl-beta-D-glucosaminidase in predicting the prognosis of antenatal hydronephrosis.

IF 2.5 3区医学 Q2 UROLOGY & NEPHROLOGY

Investigative and Clinical Urology Pub Date : 2024-05-01 DOI:10.4111/icu.20240091

Kwanjin Park, Kyeong Kim, Young Jae Im

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引用次数: 0

Abstract

Purpose: Urinary biomarkers are known to be able to diagnose renal damage caused by obstruction at an early stage. We evaluated the usefulness of urine N-acetyl-beta-D-glucosaminidase (NAG) to determine the prognosis of antenatal hydronephrosis.

Materials and methods: From January 2019 to December 2021, a retrospective study was performed on patients with grade 3 or 4 hydronephrosis. We analyzed the ultrasonographic findings and the urinary NAG/Cr ratio between the laparoscopic pyeloplasty (LP) group and active surveillance (AS) group.

Results: A total of 21 children underwent LP for ureteropelvic junction (UPJ) obstruction and 14 children underwent AS. The mean age at the time of examination was 3.7 months (1.7-7.5 months) in the LP and 5.2 months (0.5-21.5 months) in the AS (p=0.564). The mean anteroposterior pelvic diameter was 30.0 mm (15.0-49.0 mm) in the LP and 16.7 mm (9.0-31.3 mm) in the AS (p=0.003). The mean renal parenchymal thickness was 2.6 mm (1.2-3.7 mm) in the LP and 3.8 mm (2.9-5.5 mm) in the AS (p=0.017). The urinary NAG/Cr ratio was 26.1 IU/g (9.8-47.4 IU/g) in the LP and 11.1 IU/g (2.6-18.1 IU/g) in the AS (p=0.003). After LP, the urinary NAG/Cr ratio was significantly reduced to 10.4 IU/g (3.4-14.2 IU/g) (p=0.023).

Conclusions: The urinary NAG/Cr ratio, one of the biomarkers of acute renal injury, is closely related to the degree of hydronephrosis. Therefore, it may be useful to determine whether to perform surgery on the UPJ obstruction and to predict the prognosis.

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尿液中的 N-乙酰-beta-D-葡萄糖苷酶在预测产前肾积水预后中的作用。

目的：众所周知，尿液生物标志物能够早期诊断梗阻引起的肾损伤。我们评估了尿液 N-乙酰基-beta-D-葡萄糖苷酶（NAG）在判断产前肾积水预后方面的作用：2019年1月至2021年12月，我们对3级或4级肾积水患者进行了回顾性研究。我们分析了腹腔镜肾盂成形术（LP）组和积极监测（AS）组之间的超声波检查结果和尿NAG/Cr比值：共有21名儿童因输尿管肾盂连接处（UPJ）梗阻接受了腹腔镜肾盂成形术（LP），14名儿童接受了腹腔镜肾盂成形术（AS）。接受 LP 检查时的平均年龄为 3.7 个月（1.7-7.5 个月），接受 AS 检查时的平均年龄为 5.2 个月（0.5-21.5 个月）（P=0.564）。LP患者的平均骨盆前后直径为30.0毫米（15.0-49.0毫米），AS患者为16.7毫米（9.0-31.3毫米）（P=0.003）。LP患者的平均肾实质厚度为2.6毫米（1.2-3.7毫米），AS患者为3.8毫米（2.9-5.5毫米）（P=0.017）。LP患者的尿NAG/Cr比值为26.1 IU/g（9.8-47.4 IU/g），AS患者为11.1 IU/g（2.6-18.1 IU/g）（P=0.003）。LP后，尿液NAG/Cr比值明显降低至10.4 IU/g（3.4-14.2 IU/g）（p=0.023）：结论：尿 NAG/Cr 比值是急性肾损伤的生物标志物之一，与肾积水程度密切相关。结论：尿 NAG/Cr 比值是急性肾损伤的生物标志物之一，与肾积水程度密切相关，因此可用于确定是否对 UPJ 梗阻进行手术以及预测预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Investigative and Clinical Urology Medicine-Urology

CiteScore

4.10

自引率

4.30%

发文量

审稿时长

4 weeks

期刊介绍： Investigative and Clinical Urology (Investig Clin Urol, ICUrology) is an international, peer-reviewed, platinum open access journal published bimonthly. ICUrology aims to provide outstanding scientific and clinical research articles, that will advance knowledge and understanding of urological diseases and current therapeutic treatments. ICUrology publishes Original Articles, Rapid Communications, Review Articles, Special Articles, Innovations in Urology, Editorials, and Letters to the Editor, with a focus on the following areas of expertise: • Precision Medicine in Urology • Urological Oncology • Robotics/Laparoscopy • Endourology/Urolithiasis • Lower Urinary Tract Dysfunction • Female Urology • Sexual Dysfunction/Infertility • Infection/Inflammation • Reconstruction/Transplantation • Geriatric Urology • Pediatric Urology • Basic/Translational Research One of the notable features of ICUrology is the application of multimedia platforms facilitating easy-to-access online video clips of newly developed surgical techniques from the journal''s website, by a QR (quick response) code located in the article, or via YouTube. ICUrology provides current and highly relevant knowledge to a broad audience at the cutting edge of urological research and clinical practice.